Evidence map›Paper›PMID 34524885›Full record

ArticleJournal of clinical microbiology2021

Characterization of Enteric Disease in Children by Use of a Low-Cost Specimen Preservation Method.

Amanda K Debes, Shaoming Xiao, Jie Liu, Allison Shaffer, Paul Scalzo, Etienne Guenou, Landry Beyala, Goura Andre Pascal, Anthony Njimbia Chebe, Hirma Tchio-Nighie and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Amanda K DebesDepartment of International Health, Johns Hopkins Universitygrid.21107.35 Bloomberg School of Public Health, Baltimore, Maryland, USA.ORCID 0000-0003-4006-073X
Shaoming XiaoDepartment of International Health, Johns Hopkins Universitygrid.21107.35 Bloomberg School of Public Health, Baltimore, Maryland, USA.
Jie LiuUniversity of Virginiagrid.27755.32, Charlottesville, Virginia, USA.ORCID 0000-0003-2658-5249
Allison ShafferDepartment of International Health, Johns Hopkins Universitygrid.21107.35 Bloomberg School of Public Health, Baltimore, Maryland, USA.
Paul ScalzoDepartment of International Health, Johns Hopkins Universitygrid.21107.35 Bloomberg School of Public Health, Baltimore, Maryland, USA.
Etienne GuenouMeilleur Accès aux Soins de Santé, Yaoundé, Cameroon.
Landry BeyalaMeilleur Accès aux Soins de Santé, Yaoundé, Cameroon.
Goura Andre PascalMeilleur Accès aux Soins de Santé, Yaoundé, Cameroon.
Anthony Njimbia ChebeMeilleur Accès aux Soins de Santé, Yaoundé, Cameroon.
Hirma Tchio-NighieMeilleur Accès aux Soins de Santé, Yaoundé, Cameroon.
Nafack Sonkeng SoniaMeilleur Accès aux Soins de Santé, Yaoundé, Cameroon.
Malathi RamDepartment of International Health, Johns Hopkins Universitygrid.21107.35 Bloomberg School of Public Health, Baltimore, Maryland, USA.
David A SackDepartment of International Health, Johns Hopkins Universitygrid.21107.35 Bloomberg School of Public Health, Baltimore, Maryland, USA.
Jerome AteudjieuMeilleur Accès aux Soins de Santé, Yaoundé, Cameroon.
Johns Hopkins University · USOrganisation de Coordination pour la lutte contre les Endémies en Afrique Centrale · CMUniversité de Dschang · CMUniversity of Virginia · US

Funding

Epidemiology and Ecology of Cholera in AfricaR01AI123422 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Amanda Kay Debes, DAVID A SACK · 2017 to 2026
$6.6M
Bill & Melinda Gates Foundation OPP1142763NIAID NIH HHS R01 AI123422NIAID NIH HHS R01AI123422
6 · The paper itself

Abstract

Diarrhea is a leading cause of death in children under five. Molecular methods exist for the rapid detection of enteric pathogens; however, the logistical costs of storing stool specimens limit applicability. We sought to demonstrate that dried specimens preserved using filter paper can be used to identify diarrheal diseases causing significant morbidity among children in resource-constrained countries. A substudy was nested into cholera surveillance in Cameroon. Enrollment criteria included enrollment between 1 August 2016 and 1 October 2018, age of <18 years, availability of a stool specimen, and having three or more loose stools within 24 h with the presence of dehydration and/or blood. A total of 7,227 persons were enrolled, of whom 2,746 met enrollment criteria and 337 were included in this analysis using the enteric TaqMan array card. Bacterial pathogens were compared to severity of diarrhea, age, and sex, among other variables. One hundred seven were positive for enterotoxigenic Escherichia coli, of which 40.2% (

Indexed as

Enterotoxigenic Escherichia coliEscherichia coli InfectionsAdolescentChildDiarrheaEnterotoxinsHumansEnterotoxinsdiagnosticsenteric pathogensentericsETECpediatric infectious diseasepediatricsShigella

Identifiers

PMID34524885
PMCPMC8601215
OpenAlexW3199144255

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.