Evidence map›Paper›PMID 34524684›Full record

ArticleEuropean journal of immunology2022

ACKR1 favors transcellular over paracellular T-cell diapedesis across the blood-brain barrier in neuroinflammation in vitro.

Luca Marchetti, David Francisco, Sasha Soldati, Neda Haghayegh Jahromi, Sara Barcos, Isabelle Gruber, Javier R Pareja, Aude Thiriot, Ulrich von Andrian, Urban Deutsch and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in European journal of immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. The emerging role of T cells in depression.Frontiers in psychiatry · 2026
    Review
  8. Review
  9. The blood-brain barrier: a help and a hindrance.Brain : a journal of neurology · 2025
    Review
  10. Article
  11. Review
  12. Review
  13. Atypical chemokine receptors in the immune system.Nature reviews. Immunology · 2024
    Review
  14. Article
  15. Review
  16. Article
  17. Modeling Brain Vasculature Immune Interactions In Vitro.Cold Spring Harbor perspectives in medicine · 2023
    Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Luca MarchettiTheodor Kocher Institute, University of Bern, Bern, Switzerland.
David FranciscoInterfaculty Bioinformatics Unit and Swiss Institute of Bioinformatics, University of Bern, Bern, Switzerland.
Sasha SoldatiTheodor Kocher Institute, University of Bern, Bern, Switzerland.
Neda Haghayegh JahromiTheodor Kocher Institute, University of Bern, Bern, Switzerland.
Sara BarcosTheodor Kocher Institute, University of Bern, Bern, Switzerland.
Isabelle GruberTheodor Kocher Institute, University of Bern, Bern, Switzerland.
Javier R ParejaTheodor Kocher Institute, University of Bern, Bern, Switzerland.
Aude ThiriotDepartment of Immunology and Center for Immune Imaging, Harvard Medical School, Boston, Massachusetts, USA.
Ulrich von AndrianDepartment of Immunology and Center for Immune Imaging, Harvard Medical School, Boston, Massachusetts, USA.
Urban DeutschTheodor Kocher Institute, University of Bern, Bern, Switzerland.
Ruth LyckTheodor Kocher Institute, University of Bern, Bern, Switzerland.
Rémy BruggmannInterfaculty Bioinformatics Unit and Swiss Institute of Bioinformatics, University of Bern, Bern, Switzerland.
Britta EngelhardtTheodor Kocher Institute, University of Bern, Bern, Switzerland.ORCID 0000-0003-3059-9846
University of Bern · CHHarvard University · US

Funding

Intravascular Immune Surveillance by Anti-viral T CellsR01AI155865 · NIAID · HARVARD MEDICAL SCHOOL · PI VON ANDRIAN, ULRICH H · 2021 to 2025
$3.2M
Regulation of Skin Inflammation by Nociceptive Sensory NeuronsR01AR068383 · NIAMS · HARVARD MEDICAL SCHOOL · PI VON ANDRIAN, ULRICH H · 2015 to 2019
$1.9M
NIAID NIH HHS R01 AI155865NIAMS NIH HHS R01 AR068383
6 · The paper itself

Abstract

The migration of CD4

Indexed as

Blood-Brain BarrierCD4-Positive T-LymphocytesDuffy Blood-Group SystemEncephalomyelitis, Autoimmune, ExperimentalMemory T CellsMultiple SclerosisReceptors, Cell SurfaceTransendothelial and Transepithelial MigrationAnimalsInflammationMiceMice, KnockoutAckr1 protein mouseDuffy Blood-Group SystemReceptors, Cell Surfaceatypical chemokine receptor 1blood-brain barrierT celltranscellular diapedesis

Identifiers

PMID34524684
PMCPMC9293480
OpenAlexW3199907313

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.