Evidence map›Paper›PMID 34524669›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2021

Ex Vivo Expansion of Th2-Polarizing Immunotherapeutic iNKT Cells from Human Peripheral Blood.

Natasha K Khatwani, Kelly J Andrews, Asha B Pillai

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Natasha K Khatwani *Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA.
Kelly J Andrews *Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA.
Asha B PillaiDepartment of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA. asha.pillai@med.miami.edu.
Sylvester Comprehensive Cancer Center · USBeckman Coulter Foundation · US

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Shondra Michelle Miller · 1985 to 2026
$166.9M
Tumor Biology Research ProgramP30CA240139 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Stephen D. Nimer · 2019 to 2026
$24.1M
NCI NIH HHS P30 CA021765NCI NIH HHS P30 CA240139
6 · The paper itself

Abstract

iNKT cells, classified as innate lymphocytes with invariant TCRs, have been highlighted as a putative, "off-the-shelf" cellular immunotherapeutic strategy for the treatment of malignant and nonmalignant diseases. However, their paucity in human blood limits their immunotherapeutic applications. Herein we describe a rigorously optimized 21-day ex vivo expansion method to achieve log-fold increases in immunotherapeutic human iNKT cells.

Indexed as

Natural Killer T-CellsHumansImmunotherapyReceptors, Antigen, T-CellTh2 CellsReceptors, Antigen, T-CellAdoptive cellular therapyBone marrow transplantationCancer immunotherapyCytotoxicityHematopoietic stem cell transplantationImmunotherapyiNKT cellsLeukemiaNKT cellsTransplantation

Identifiers

PMID34524669
PMCPMC8733937
OpenAlexW3199742627

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.