Evidence map›Paper›PMID 34524657›Full record

ReviewMethods in molecular biology (Clifton, N.J.)2021

Genetic Analysis of iNKT Cell Development and Function.

Julie Sahler, Orchi Anannya, Candice Limper, Brian Imbiakha, Tim Pierpont, Avery August

Abstract readReview
PubMed Publisher
In one paragraph

Review in Methods in molecular biology (Clifton, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Protective effects ofFrontiers in pharmacology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Julie Sahler *Department of Microbiology and Immunology, Cornell Center for Immunology, Cornell Institute for Host Microbe and Defense, Cornell University, Ithaca, NY, USA.
Orchi Anannya *Department of Microbiology and Immunology, Cornell Center for Immunology, Cornell Institute for Host Microbe and Defense, Cornell University, Ithaca, NY, USA.
Candice Limper *Department of Microbiology and Immunology, Cornell Center for Immunology, Cornell Institute for Host Microbe and Defense, Cornell University, Ithaca, NY, USA.
Brian Imbiakha *Department of Microbiology and Immunology, Cornell Center for Immunology, Cornell Institute for Host Microbe and Defense, Cornell University, Ithaca, NY, USA.
Tim Pierpont *Department of Microbiology and Immunology, Cornell Center for Immunology, Cornell Institute for Host Microbe and Defense, Cornell University, Ithaca, NY, USA.
Avery August *Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA. averyaugust@cornell.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural killer T (NKT) cells are among the immediate and early responding immune cells and are important players in autoimmune diseases and tumor immunity. This unique subset of T cells shares properties of natural killer cells and T cells. Proper identification and characterization of NKT cell subsets is essential to understand the function and involvement of these understudied immune cells in various diseases. This review aims to summarize the known methods for identifying and characterizing NKT cells. NKT cells are divided into Type I (or invariant) and Type II, with either limited or broad TCR repertoires, respectively, that generally respond to glycolipids presented on the nonclassical MHC, CD1d. Type I NKT cells or invariant NKT cells (iNKT) are the most well studied and can be further subdivided into NKT1, NKT2, or NKT17 populations, classified based on their functional capacity. Conversely, less is known about Type II NKT cells because they have a more diverse TCR repertoire which make them hard to identify. However, genetic analyses have shed light on the development and function of all NKT subsets, which aids in their characterization. Further exploration of the role of NKT cells in various diseases will reveal the intricacies and importance of their novel functions.

Indexed as

Natural Killer T-CellsAntigens, CD1dGlycolipidsReceptors, Antigen, T-CellAntigens, CD1dGlycolipidsReceptors, Antigen, T-CellCD1dCD1d/α-galactosyl ceramide tetramersNatural killer T cellsα-Galactosyl ceramide

Identifiers

PMID34524657

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.