Evidence map›Paper›PMID 34524623›Full record

ArticleInternal and emergency medicine2022

Lung cancer and interstitial lung diseases: the lack of prognostic impact of lung cancer in IPF.

Loredana Carobene, Donatella Spina, Maria Giulia Disanto, Claudio Micheletto, Maria Antonietta Mazzei, Piero Paladini, Claudia Ghiribelli, Elena Bargagli, Paola Rottoli

Erratum issuedAbstract read
In one paragraph

Article in Internal and emergency medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Current oncology (Toronto, Ont.) · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Impact of pulmonary fibrosis on tumor measurements.Journal of thoracic disease · 2024
    Article
  7. Article
  8. Review
  9. TLR/WNT: A Novel Relationship in Immunomodulation of Lung Cancer.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Loredana CarobeneCardio-Thoracic Department, Respiratory Unit, Verona Integrated University Hospital, University of Verona, Square Aristide Stefani, 1, Verona, Italy. loredana.carobene@aovr.veneto.it.ORCID 0000-0003-1903-0114
Donatella SpinaPathology Unit, Siena University Hospital, Siena, Italy.
Maria Giulia DisantoPathology Unit, Siena University Hospital, Siena, Italy.
Claudio MichelettoCardio-Thoracic Department, Respiratory Unit, Verona Integrated University Hospital, University of Verona, Square Aristide Stefani, 1, Verona, Italy. claudio.micheletto@univr.it.
Maria Antonietta MazzeiDiagnostic Imaging Unit, Siena University Hospital, Siena, Italy.
Piero PaladiniThoracic Surgery Unit, Siena University Hospital, Siena, Italy.
Claudia GhiribelliThoracic Surgery Unit, Siena University Hospital, Siena, Italy.
Elena BargagliRespiratory Disease and Lung Transplant Unit, Siena University Hospital, Siena, Italy.
Paola RottoliRespiratory Disease and Lung Transplant Unit, Siena University Hospital, Siena, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung Cancer (LC) is the first cause of death worldwide. Recently increased interest in interstitial lung diseases (ILD) has highlighted an association with lung cancer, offering interesting insights into the pathogenesis of the latter. Describe the association between lung cancer and ILD and evaluate the impact of LC on survival in these populations. We collected clinical, radiological, histologic data of 53 cases of advanced pulmonary fibrosis with lung cancer: 17 with UIP pattern (usual interstitial pneumonia, UIP/IPF-LC) and 36 with non-UIP pattern (ILD-LC). Adenocarcinoma was the most frequent histological subtype of lung cancer in all three groups and in UIP/IPF-LC developed in the lung periphery and in an advanced fibrosis context. Patients with DLCO% < 38% showed survival < 10 months, irrespective of group and development of carcinoma in UIP/IPF does not necessarily affect survival, unlike in SR-ILD. Our results confirm that the oncogenic mechanism is closely linked to fibrotic and inflammatory processes and that the development of carcinoma affects survival in SR-ILD but not in IPF.

Indexed as

CarcinomaIdiopathic Pulmonary FibrosisLung Diseases, InterstitialLung NeoplasmsHumansLungPrognosisRetrospective StudiesTomography, X-Ray ComputedIdiopathic pulmonary fibrosisInterstitial lung diseaseLung cancerSurvival

Identifiers

PMID34524623
PMCPMC8964539

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.