Evidence map›Paper›PMID 34524618›Full record

ReviewClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2022

Circulating exosomal miRNAs and cancer early diagnosis.

L Zhu, L Zhao, Q Wang, S Zhong, X Guo, Y Zhu, J Bao, K Xu, S Liu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Body mass index and cancer survival: a meta-analysis of cohort studies.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Pooled it
  2. Review
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  9. Genetic variants in miR-146a and miR-196a2 in endometriosis: a Brazilian study.Revista da Associacao Medica Brasileira (1992) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

L Zhu *Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China.
L Zhao *Hong Kong Chinese Medicine Clinical Study Centre, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
Q WangDepartment of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, 141 86, Huddinge, Sweden.
S ZhongHangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China.
X GuoCentre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
Y ZhuSchool of Medicine, Beijing University of Chinese Medicine, Beijing, China.
J BaoHangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China. zjbjf1972@aliyun.com.
K XuCentre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. keyangxu@qq.com.ORCID http://orcid.org/0000-0002-7049-2528
S LiuHangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China. lsr85463990@126.com.

Funding

Hangzhou Science and Technology Bureau 20181228Y22Hangzhou Science and Technology Development Project 20172016A03National Key Research and Development Program of China 2018YFC1705700Zhejiang Natural Science Foundation LSY19H030002
6 · The paper itself

Abstract

Microribonucleic acids (miRNAs) are small non-coding ribonucleic acids (ncRNAs), which can affect recognition of homologous sequences and interfere with transcription. It plays key roles in the initiation, development, resistance, metastasis or recurrence of cancers. Identifying circulatory indicators will positively improve the prognosis and quality of life of patients with early cancer. Previous studies have shown that miRNA is highly involved in cancer. In addition, miRNA derived from cancers can be encapsulated as exosomes and further extracted into circulatory systems to realize malignant functions. It indicates that circulating exosome-derived miRNAs have the potential to replace conventional biomarkers as cancer derived exosomes carrying miRNAs can be identified by specific markers and might be more stable and accurate for early diagnosis.

Indexed as

Early Detection of CancerExosomesHumansMicroRNAsNeoplasmsMicroRNAsBiomarkerCancerEarly diagnosisExosomemicroRNA

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.