ReviewCurrent topics in microbiology and immunology2023
A Guide to Preclinical Models of Zoster-Associated Pain and Postherpetic Neuralgia.
Review in Current topics in microbiology and immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Construction and validation of a prediction system for postherpetic neuralgia: based on meta-analysis.Scientific reports · 2026Pooled it
- Comparative Efficacy of Short-Term Spinal Cord Stimulation for Subacute Zoster-Associated Pain: A Three-Group Propensity Score-Matched Analysis.Pain and therapy · 2026Article
- Phase-specific involvement of BDNF-TrkB signaling in HSV-1-induced herpetic pain and its transition to postherpetic neuralgia-like pain.Pharmacological reports : PR · 2026Article
- Varicella Zoster Virus Infection: Clinical Features, Molecular Pathogenesis, Treatment, and Prevention.MedComm · 2026Review
- The Factors Influencing the Efficacy of Pregabalin Combined With Lidocaine in the Treatment of Postherpetic Neuralgia Patients: An Analysis.Immunity, inflammation and disease · 2026Article
- Ultrasound-guided retro-neural transforaminal injection with fluoroscopic confirmation for zoster-associated pain: a retrospective propensity score-matched analysis.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Virally-initiated pain states: phenotypes, mechanisms, and future directions.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Advantages of Blunt Radiofrequency Needles in CT-Guided Dorsal Root Ganglion Pulsed Radiofrequency for the Treatment of Zoster-Associated Pain.Anesthesiology research and practice · 2025Article
- The Use of Tricyclic Antidepressants for Postherpetic Neuralgia - A Case Series.Health psychology research · 2025Article
- The efficacy and prognosis analysis of short-term spinal cord stimulation in the treatment of zoster-associated pain: a retrospective study.Frontiers in neurology · 2025Article
- Comparative efficacy of short-term spinal cord stimulation and pulsed radiofrequency in zoster-associated pain: a stratified database study.Frontiers in neurology · 2025Article
- A Comparison of Short-Term Peripheral Nerve Stimulation and Pulsed Radiofrequency in the Treatment of Postherpetic Neuralgia.Journal of pain research · 2024Article
- Analysis of Risk Factors and Development and Validation of a Dynamic Nomogram for Postherpetic Neuralgia: A Retrospective Study.Journal of pain research · 2024Article
- Disrupted Balance of Short- and Long-Range Functional Connectivity Density in Patients with Herpes Zoster or Postherpetic Neuralgia: A Resting-State fMRI Study.Journal of pain research · 2024Article
- Metabolomics profiling in predicting of post-herpetic neuralgia induced by varicella zoster.Scientific reports · 2023Article
- Selective retention of virus-specific tissue-resident T cells in healed skin after recovery from herpes zoster.Nature communications · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Reactivation of latent varicella-zoster virus (VZV) causes herpes zoster (HZ), which is commonly accompanied by acute pain and pruritus over the time course of a zosteriform rash. Although the rash and associated pain are self-limiting, a considerable fraction of HZ cases will subsequently develop debilitating chronic pain states termed postherpetic neuralgia (PHN). How VZV causes acute pain and the mechanisms underlying the transition to PHN are far from clear. The human-specific nature of VZV has made in vivo modeling of pain following reactivation difficult to study because no single animal can reproduce reactivated VZV disease as observed in the clinic. Investigations of VZV pathogenesis following primary infection have benefited greatly from human tissues harbored in immune-deficient mice, but modeling of acute and chronic pain requires an intact nervous system with the capability of transmitting ascending and descending sensory signals. Several groups have found that subcutaneous VZV inoculation of the rat induces prolonged and measurable changes in nociceptive behavior, indicating sensitivity that partially mimics the development of mechanical allodynia and thermal hyperalgesia seen in HZ and PHN patients. Although it is not a model of reactivation, the rat is beginning to inform how VZV infection can evoke a pain response and induce long-lasting alterations to nociception. In this review, we will summarize the rat pain models from a practical perspective and discuss avenues that have opened for testing of novel treatments for both zoster-associated pain and chronic PHN conditions, which remain in critical need of effective therapies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.