ArticleThe Plant cell2021
STOP1 activates NRT1.1-mediated nitrate uptake to create a favorable rhizospheric pH for plant adaptation to acidity.
Article in The Plant cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 91 citations in OpenAlex.
- Genome-wide analyses of NPF and NRT2 reveal a potential role for a key gene, CqNRT2.2, in the quinoa response to nitrate.BMC plant biology · 2026Article
- BRAHMA represses STOP1-NRT1.1 module to control plant rhizosphere alkalization and acid stress adaptation.Nature communications · 2026Article
- NRT1.1 as central signaling hub orchestrating plant growth and stress trade-offs.Frontiers in plant science · 2026Review
- A novel SlSTOP1-SlHAK5-cytosolic pH feedback loop drives dual adaptation to proton and aluminum toxicity in tomato.Horticulture research · 2025Article
- A novel function for the transcription factor sensitive to proton rhizotoxicity1 in promoting anthocyanin accumulation in strawberry.Plant biotechnology journal · 2025Article
- Trans-organ analysis of gene co-expression networks reveals a mobile long-distance regulator that balances shoot and root development in Arabidopsis.Nature plants · 2025Article
- Non-Invasive Micro-Test Technology in Plant Physiology Under Abiotic Stress: From Mechanism to Application.Plants (Basel, Switzerland) · 2025Review
- The RAE1-STOP1 module regulates ABA sensitivity in early seedlings of Arabidopsis.BMC plant biology · 2025Article
- Plant Signaling Hormones and Transcription Factors: Key Regulators of Plant Responses to Growth, Development, and Stress.Plants (Basel, Switzerland) · 2025Review
- Transcriptome analysis reveals nutrient deprivation reduces nitrate content in lettuce (Frontiers in plant science · 2025Article
- Functional crosstalk between nitrate and ammonium transporters in N acquisition and pH homeostasis.Frontiers in plant science · 2025Review
- SnRK1α1-mediated RBOH1 phosphorylation regulates reactive oxygen species to enhance tolerance to low nitrogen in tomato.The Plant cell · 2024Article
- Article
- S-nitrosoglutathione reductase disfavors cadmium tolerance in shoots of Arabidopsis.Scientific reports · 2024Article
- SlSTOP1-regulatedHorticulture research · 2024Article
- Towards Sustainable Productivity of Greenhouse Vegetable Soils: Limiting Factors and Mitigation Strategies.Plants (Basel, Switzerland) · 2024Review
- MicroRNAs as potent regulators in nitrogen and phosphorus signaling transduction and their applications.Stress biology · 2024Review
- Phosphorus uptake, transport, and signaling in woody and model plants.Forestry research · 2024Review
- Protein Phosphorylation Orchestrates Acclimations of Arabidopsis Plants to Environmental pH.Molecular & cellular proteomics : MCP · 2024Article
- Overexpression ofInternational journal of molecular sciences · 2023Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protons (H+) in acidic soils arrest plant growth. However, the mechanisms by which plants optimize their biological processes to diminish the unfavorable effects of H+ stress remain largely unclear. Here, we showed that in the roots of Arabidopsis thaliana, the C2H2-type transcription factor STOP1 in the nucleus was enriched by low pH in a nitrate-independent manner, with the spatial expression pattern of NITRATE TRANSPORTER 1.1 (NRT1.1) established by low pH required the action of STOP1. Additionally, the nrt1.1 and stop1 mutants, as well as the nrt1.1 stop1 double mutant, had a similar hypersensitive phenotype to low pH, indicating that STOP1 and NRT1.1 function in the same pathway for H+ tolerance. Molecular assays revealed that STOP1 directly bound to the promoter of NRT1.1 to activate its transcription in response to low pH, thus upregulating its nitrate uptake. This action improved the nitrogen use efficiency (NUE) of plants and created a favorable rhizospheric pH for root growth by enhancing H+ depletion in the rhizosphere. Consequently, the constitutive expression of NRT1.1 in stop1 mutants abolished the hypersensitive phenotype to low pH. These results demonstrate that STOP1-NRT1.1 is a key module for plants to optimize NUE and ensure better plant growth in acidic media.
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