Evidence map›Paper›PMID 34524369›Full record

ArticleJournal of applied oral science : revista FOB2021

Effect of rhBMP-2 applied with a 3D-printed titanium implant on new bone formation in rabbit calvarium.

Ryu Jaeyoung, Hyo-Sun Kang, Byung-Hun Kang, Seunggon Jung, Min-Suk Kook, O H Hee-Kyun, Ji-Yeon Jung, Hong-Ju Park

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied oral science : revista FOB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ryu JaeyoungChonnam National University, Department of Oral and Maxillofacial Surgery, Gwangju, Republic of Korea.ORCID http://orcid.org/0000-0002-2940-5875
Hyo-Sun KangChonnam National University, Department of Oral and Maxillofacial Surgery, Gwangju, Republic of Korea.ORCID http://orcid.org/0000-0001-8901-2283
Byung-Hun KangChonnam National University, Department of Oral and Maxillofacial Surgery, Gwangju, Republic of Korea.ORCID http://orcid.org/0000-0001-6905-3782
Seunggon JungChonnam National University, Department of Oral and Maxillofacial Surgery, Gwangju, Republic of Korea.ORCID http://orcid.org/0000-0003-2008-3205
Min-Suk KookChonnam National University, Department of Oral and Maxillofacial Surgery, Gwangju, Republic of Korea.ORCID http://orcid.org/0000-0002-8053-8534
O H Hee-KyunChonnam National University, Department of Oral and Maxillofacial Surgery, Gwangju, Republic of Korea.ORCID http://orcid.org/0000-0003-3103-5815
Ji-Yeon JungChonnam National University, Department of Oral Physiology, Gwangju, Republic of Korea.ORCID http://orcid.org/0000-0002-4419-8077
Hong-Ju ParkChonnam National University, Department of Oral and Maxillofacial Surgery, Gwangju, Republic of Korea.ORCID http://orcid.org/0000-0001-7652-5397
Chonnam National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study sought to compare the biocompatibility of a three-dimensional (3D)-printed titanium implant with a conventional machined titanium product, as well as the effect of such implant applied with recombinant human Bone Morphogenetic Protein Type 2 (rhBMP-2) for guided bone regeneration. METHODOLOGY: Disk-shaped titanium specimens fabricated either by the conventional machining technique or by the 3D-printing technique were compared by MC3T3-E1 cells cytotoxicity assay. New bone formation was evaluated using a rapid prototype titanium cap applied to the calvaria of 10 rabbits, which were divided into two groups: one including an atelopeptide collagen plug on one side of the cap (group I) and the other including a plug with rhBMP-2 on the other side (group II). At six and 12 weeks after euthanasia, rabbits calvaria underwent morphometric analysis through radiological and histological examination.

resultsThrough the cytotoxicity assay, we identified a significantly higher number of MC3T3-E1 cells in the 3D-printed specimen when compared to the machined specimen after 48 hours of culture. Moreover, morphometric analysis indicated significantly greater bone formation at week 12 on the side where rhBMP-2 was applied when evaluating the upper portion immediately below the cap.

conclusionThe results suggest that 3D-printed titanium implant applied with rhBMP-2 enables new bone formation.

Indexed as

OsteogenesisTitaniumAnimalsBone Morphogenetic Protein 2Bone RegenerationPrinting, Three-DimensionalRabbitsRecombinant ProteinsSkullTransforming Growth Factor betaBone Morphogenetic Protein 2Recombinant ProteinsTitaniumTransforming Growth Factor beta

Identifiers

PMID34524369
PMCPMC8428818
OpenAlexW3199399910

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.