Evidence map›Paper›PMID 34524083›Full record

ArticleeLife2021

A nascent polypeptide sequence modulates DnaA translation elongation in response to nutrient availability.

Michele Felletti, Cédric Romilly, E Gerhart H Wagner, Kristina Jonas

Abstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Polyphosphate synthesis is essential for phosphate and ATP homeostasis during nutrient upshift.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michele FellettiScience for Life Laboratory and Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.ORCID 0000-0002-2494-1345
Cédric RomillyDepartment of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.ORCID 0000-0003-2129-6667
E Gerhart H WagnerDepartment of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.ORCID 0000-0003-2771-0486
Kristina JonasScience for Life Laboratory and Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.ORCID 0000-0002-1469-4424

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ability to regulate DNA replication initiation in response to changing nutrient conditions is an important feature of most cell types. In bacteria, DNA replication is triggered by the initiator protein DnaA, which has long been suggested to respond to nutritional changes; nevertheless, the underlying mechanisms remain poorly understood. Here, we report a novel mechanism that adjusts DnaA synthesis in response to nutrient availability in

Indexed as

Bacterial ProteinsCulture MediaDNA-Binding ProteinsCaulobacter crescentusDNA ReplicationPeptide Chain Elongation, TranslationalPeptidesRNA, MessengerBacterial ProteinsCulture MediaDnaA protein, BacteriaDNA-Binding ProteinsPeptidesRNA, MessengerbacteriachromosomesDNA replicationE. coligene expressioninfectious diseasemicrobiologymRNAribosomestarvationtranslation

Identifiers

PMID34524083
PMCPMC8443254

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.