Evidence map›Paper›PMID 34523997›Full record

ArticleMicrobiology spectrum2021

Synovial Fluid-Induced Aggregation Occurs across Staphylococcus aureus Clinical Isolates and is Mechanistically Independent of Attached Biofilm Formation.

Amelia Staats, Peter W Burback, Mostafa Eltobgy, Dana M Parker, Amal O Amer, Daniel J Wozniak, Shu-Hua Wang, Kurt B Stevenson, Kenneth L Urish, Paul Stoodley

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Matrix porosity is associated withbioRxiv : the preprint server for biology · 2024
    Article
  5. Article
  6. Genotypic and phenotypic characterization ofbioRxiv : the preprint server for biology · 2024
    Article
  7. Review
  8. Journal of bacteriology · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Non-deacetylated poly-Frontiers in microbiology · 2022
    Article
  13. Development of an artificial synovial fluid useful for studyingFrontiers in cellular and infection microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Amelia StaatsDepartment of Microbiology, The Ohio State Universitygrid.261331.4, Columbus, Ohio, USA.ORCID 0000-0001-7563-1403
Peter W BurbackDepartment of Microbial Infection and Immunity, The Ohio State Universitygrid.261331.4, Columbus, Ohio, USA.ORCID 0000-0001-9093-7216
Mostafa EltobgyDepartment of Microbial Infection and Immunity, The Ohio State Universitygrid.261331.4, Columbus, Ohio, USA.ORCID 0000-0002-4056-7429
Dana M ParkerArthritis and Arthroplasty Design Group, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Amal O AmerDepartment of Microbial Infection and Immunity, The Ohio State Universitygrid.261331.4, Columbus, Ohio, USA.ORCID 0000-0003-4487-7536
Daniel J WozniakDepartment of Microbiology, The Ohio State Universitygrid.261331.4, Columbus, Ohio, USA.ORCID 0000-0003-4592-4816
Shu-Hua WangDepartment of Internal Medicine, Division of Infectious Diseases, The Ohio State Universitygrid.261331.4 Wexner Medical Center, Columbus, Ohio, USA.ORCID 0000-0001-8006-2401
Kurt B StevensonDepartment of Internal Medicine, Division of Infectious Diseases, The Ohio State Universitygrid.261331.4 Wexner Medical Center, Columbus, Ohio, USA.
Kenneth L UrishArthritis and Arthroplasty Design Group, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-4511-1308
Paul StoodleyDepartment of Microbial Infection and Immunity, The Ohio State Universitygrid.261331.4, Columbus, Ohio, USA.ORCID 0000-0001-6069-273X
The Ohio State University · USThe Ohio State University Wexner Medical Center · USUniversity of Pittsburgh · USUniversity of Southampton · GB

Funding

Unraveling the role of the CFTR ion channel in susceptibility to SARS-CoV-2 infection and inflammationR01AI124121 · NIAID · OHIO STATE UNIVERSITY · PI AMER, AMAL O, CORMET-BOYAKA, ESTELLE A · 2016 to 2020
$3.7M
The biofilm matrix of P. aeruginosaR01AI143916 · NIAID · UNIVERSITY OF WASHINGTON · PI MACCOSS, MICHAEL, PARSEK, MATTHEW R. · 2019 to 2023
$2.9M
Revisiting alginate paradigmsR01AI134895 · NIAID · OHIO STATE UNIVERSITY · PI WOZNIAK, DANIEL J · 2018 to 2022
$2.5M
The role of Staphylococcus aureus aggregate formation in establishing biofilms in chronic orthopaedic periprosthetic joint infection.R01GM124436 · NIGMS · OHIO STATE UNIVERSITY · PI STOODLEY, PAUL · 2018 to 2021
$2.1M
The role of microRNA-calibrated autophagy in innate immunity and inflammationR01HL127651 · NHLBI · OHIO STATE UNIVERSITY · PI AMER, AMAL O, CORMET-BOYAKA, ESTELLE A · 2015 to 2018
$1.5M
Biofilm antibiotic tolerance in periprosthetic joint infectionK08AR071494 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI URISH, KENNETH L · 2017 to 2021
$831k
The Role of Biofilm Formation in Antibiotic Tolerant Periprosthetic Joint InfectionR03AR077602 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI URISH, KENNETH L · 2021 to 2022
$158k
NHLBI NIH HHS R01 HL127651NIAID NIH HHS R01 AI124121NIAID NIH HHS R01 AI134895NIAID NIH HHS R01 AI143916NIAMS NIH HHS K08 AR071494NIAMS NIH HHS R03 AR077602NIGMS NIH HHS R01 GM124436
6 · The paper itself

Abstract

Rapid synovial fluid-induced aggregation of Staphylococcus aureus is currently being investigated as an important factor in the establishment of periprosthetic joint infections (PJIs). Pathogenic advantages of aggregate formation have been well documented

Indexed as

AnimalsBacterial AdhesionBiofilmsCattleHip ProsthesisHumansKnee ProsthesisProsthesis-Related InfectionsSerumStaphylococcal InfectionsStaphylococcus aureusSynovial FluidSynovial MembraneaggregationbiofilminfectionjointorthopedicsS. aureusStaphylococcus aureus

Identifiers

PMID34523997
PMCPMC8557890
OpenAlexW3200342021

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.