Evidence map›Paper›PMID 34523824›Full record

ArticleJournal of cachexia, sarcopenia and muscle2021

Genetic variation in genes regulating skeletal muscle regeneration and tissue remodelling associated with weight loss in chronic obstructive pulmonary disease.

Preeti Lakshman Kumar, Ava C Wilson, Alison Rocco, Michael H Cho, Emily Wan, Brian D Hobbs, George R Washko, Victor E Ortega, Stephanie A Christenson, Xingnan Li and 19 more

Erratum issued Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT01969344 (Subpopulations and Intermediate Outcome Measures in COPD Study), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01969344 active not recruitingnot on this map

Subpopulations and Intermediate Outcome Measures in COPD Study

TypeobservationalSponsorUniversity of North Carolina, Chapel HillRan2010 to 2031Enrolled2,981ConditionsCOPD, Chronic Obstructive Pulmonary Disease, Chronic Bronchitis, Emphysema
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Therapeutic Effects of Lifei Decoction in a Murine Model of COPD Induced by LPS and Cigarette Smoke.International journal of chronic obstructive pulmonary disease · 2024
    Article
  5. Article
  6. Article
  7. Update on the Etiology, Assessment, and Management of COPD Cachexia: Considerations for the Clinician.International journal of chronic obstructive pulmonary disease · 2022
    Review
  8. Identification ofFrontiers in veterinary science · 2022
    Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors at 12 institutions in 2 countries.

Preeti Lakshman KumarDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Ava C WilsonDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Alison RoccoDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Michael H ChoChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Emily WanChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Brian D HobbsChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
George R WashkoDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Victor E OrtegaDepartment of Internal Medicine, Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Stephanie A ChristensonDivision of Pulmonary, Critical Care, Allergy, & Sleep Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
Xingnan LiDepartment of Medicine, University of Arizona College of Medicine, Tucson, AZ, USA.
J Michael WellsDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Surya P BhattDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Dawn L DeMeoChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Sharon M LutzDepartment of Population Medicine, Harvard Medical School, Boston, MA, USA.
Harry RossiterRehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor Harbor-UCLA Medical Center, Torrance, CA, USA.
Richard CasaburiRehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor Harbor-UCLA Medical Center, Torrance, CA, USA.
Stephen I RennardDepartment of Medicine, Nebraska Medical Center, Omaha, NE, USA.
David A LomasUCL Respiratory, University College London, London, UK.
Wassim W LabakiDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.
Ruth Tal-SingerCOPD Foundation, Miami, FL, USA.
Russel P BowlerDepartment of Medicine, Division of Pulmonary, Critical Care & Sleep Medicine, National Jewish Health, Denver, CO, USA.
Craig P HershChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Hemant K TiwariDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.
Mark DransfieldDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Anna Thalacker-MercerDepartment of Cell Development and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA.
Deborah A MeyersDepartment of Medicine, University of Arizona College of Medicine, Tucson, AZ, USA.
Edwin K SilvermanChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Merry-Lynn N McDonaldDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-2647-9422
COPDGene, ECLIPSE and SPIROMICS investigators
University of Alabama at Birmingham · USBrigham and Women's Hospital · USThe Lundquist Institute · USUniversity of Arizona · USCOPD Foundation · USHarvard University · USNational Jewish Health · USNebraska Medical Center · USUniversity College London · GBUniversity of California, San Francisco · USUniversity of Michigan · USWake Forest University · US

Funding

Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
SPIROMICS II: Biological underpinnings of COPD heterogeneity and progressionU01HL137880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, PRESCOTT G · 2017 to 2021
$27.9M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
Genetic and Genomic Characterization of the Occurrence and Progression of Interstitial Lung AbnormalitiesR01HL135142 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL H. CHO, GARY MATTHEW HUNNINGHAKE · 2017 to 2026
$7.7M
SPIROMICS GIC SupportU24HL141762 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J, O'NEAL, WANDA K · 2018 to 2022
$7.2M
Identifying functional variants in COPD GWAS lociR01HL137927 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHO, MICHAEL H., SILVERMAN, EDWIN K · 2017 to 2020
$3.5M
COPD Cachexia: Deciphering the Impact of Antioxidants, Iron and Mitochondrial Function Using 'Omics ApproachesR01HL153460 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MCDONALD DONNELLY, MERRY-LYNN NOELLE · 2021 to 2024
$2.7M
Determinants of 5 Year Progression of Muscle Dysfunction and Inactivity in COPDGene Participants Diversity SupplementR01HL151452 · NHLBI · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI ADAMI, ALESSANDRA, ROSSITER, HARRY B · 2020 to 2023
$1.6M
Multi-omic Subtyping of Chronic Obstructive Pulmonary DiseaseK08HL136928 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI HOBBS, BRIAN DANIEL · 2017 to 2021
$864k
Network Medicine Approaches to Cachexia in COPDR00HL121087 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MCDONALD DONNELLY, MERRY-LYNN NOELLE · 2017 to 2019
$747k
COPD cachexia: deciphering the impact of antioxidants, iron and mitochondrial function using 'omics approachesR56HL153460 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MCDONALD DONNELLY, MERRY-LYNN NOELLE · 2020 to 2020
$721k
Department of HealthNHLBI NIH HHS HHSN268200900013CNHLBI NIH HHS HHSN268200900014CNHLBI NIH HHS HHSN268200900015CNHLBI NIH HHS HHSN268200900016CNHLBI NIH HHS HHSN268200900017CNHLBI NIH HHS HHSN268200900018CNHLBI NIH HHS HHSN268200900019CNHLBI NIH HHS HHSN268200900020CNHLBI NIH HHS K08 HL136928NHLBI NIH HHS R01 HL137927NHLBI NIH HHS R01 HL151452NHLBI NIH HHS R01 HL153460NHLBI NIH HHS R56 HL153460NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NHLBI NIH HHS U01 HL137880NHLBI NIH HHS U24 HL141762NIDDK NIH HHS P30 DK079626NIH HHS K08 HL136928NIH HHS R00HL121087NIH HHS R01HL135142NIH HHS R01 HL137927NIH HHS R01 HL14714NIH HHS R01HL153460NIH HHS R56HL153460RRD VA IK2 RX002165
6 · The paper itself

Abstract

backgroundChronic obstructive pulmonary disease (COPD) is the third leading cause of death globally. COPD patients with cachexia or weight loss have increased risk of death independent of body mass index (BMI) and lung function. We tested the hypothesis genetic variation is associated with weight loss in COPD using a genome-wide association study approach.

methodsParticipants with COPD (N = 4308) from three studies (COPDGene, ECLIPSE, and SPIROMICS) were analysed. Discovery analyses were performed in COPDGene with replication in SPIROMICS and ECLIPSE. In COPDGene, weight loss was defined as self-reported unintentional weight loss > 5% in the past year or low BMI (BMI < 20 kg/m

resultsAt the single variant level, only the rs35368512 variant, intergenic to GRXCR1 and LINC02383, was associated with weight loss (odds ratio = 3.6, 95% confidence interval = 2.3-5.6, P = 3.2 × 10

conclusionsThe EFNA2 and BAIAP2 genes were significantly associated with weight loss in COPD participants. Collectively, the integrative network analyses indicated genetic variation associated with weight loss in COPD may influence skeletal muscle regeneration and tissue remodelling.

Indexed as

Genome-Wide Association StudyPulmonary Disease, Chronic ObstructiveAdultBayes TheoremGenetic VariationHumansMuscle, SkeletalNerve Tissue ProteinsRegenerationWeight LossBAIAP2 protein, humanNerve Tissue ProteinsBiomarkersCachexiaCOPDGeneticsGWASSkeletal muscle regenerationTissue remodellingWeight loss

Identifiers

PMID34523824
PMCPMC8718068
OpenAlexW3200565260

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.