Evidence map›Paper›PMID 34523755›Full record

ArticleJournal of clinical laboratory analysis2021

Plasma circular RNA hsa_circ_0001821 acts as a novel diagnostic biomarker for malignant tumors.

Yulan Song, Peng Cao, Jipeng Li

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Article in Journal of clinical laboratory analysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yulan SongBlood Purification Center, The Affiliated People's Hospital, Ningbo University, Ningbo, China.
Peng CaoDepartment of Laboratory Medicine, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China.
Jipeng LiDepartment of Central Laboratory, The Affiliated People's Hospital, Ningbo University, Ningbo, China.ORCID https://orcid.org/0000-0001-5091-8432

Funding

National Natural Science Foundation of China 81872433Zhejiang Provincial Medicine and Health Science Research Foundation of China 2018KY749
6 · The paper itself

Abstract

backgroundCircular RNAs (circRNAs) can function as key regulators of oncogenic processes. The main purpose of this study was to evaluate the expression of hsa_circ_0001821 in plasma of patients with colorectal cancer (CRC) and other malignant tumors and analyze its correlations with clinical features and diagnostic values.

methodsIn total, 467 plasma samples, including samples from 80 healthy controls, were collected between 2015 and 2019 from patients at the Affiliated People's Hospital of Ningbo University. Plasma levels of hsa_circ_0001821 were analyzed by qRT-PCR. The diagnostic value was performed using receiver operating characteristic (ROC) curve.

resultsPlasma hsa_circ_0001821 was increased in CRC patients, and high hsa_circ_0001821 expression predicted advanced stage and unfavorable in overall survival. In addition, this study showed the upregulation of hsa_circ_0001821 in plasma of lung cancer and hepatocellular carcinoma (HCC). ROC curve showed that the region under the loop for the diagnosis of CRC, HCC, and lung cancer was 0.815, 0.692, and 0.792.

conclusionPlasma hsa_circ_0001821 possibly is a novel biological marker for malignant tumors.

Indexed as

Biomarkers, TumorFemaleHumansMaleMiddle AgedNeoplasmsRNA, CircularROC CurveBiomarkers, TumorRNA, Circularbiomarkercircular RNAsmalignant cancerplasma

Identifiers

PMID34523755
PMCPMC8605135

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