SynthesisScandinavian journal of work, environment & health2021
Associations of working conditions and chronic low-grade inflammation among employees: a systematic review and meta-analysis.
Synthesis in Scandinavian journal of work, environment & health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Chronic stress in relation to clinical burnout: an integrative scoping review of definitions and measurement approaches.Frontiers in psychology · 2025Pooled it
- Shift Work, Circadian Disruption, and Immune Dysregulation: Molecular Links to Gastrointestinal Diseases and Occupational Health Implications.Diagnostics (Basel, Switzerland) · 2026Review
- Burnout and Biological Biomarkers in Emergency and Acute-Care Healthcare Workers: A Systematic Scoping Review with Evidence Mapping.Medicina (Kaunas, Lithuania) · 2026Article
- Perceived stress precedes declines in Well-being: A prospective study of stress, well-being, hair cortisol, and low-grade inflammation in hospital employees.Brain, behavior, & immunity - health · 2026Article
- Occupational health of drilling waste workers as related to microbial exposure and waste treatment methods.Annals of work exposures and health · 2025Article
- Article
- A multiscale inflammatory map: linking individual stress to societal dysfunction.Frontiers in science · 2024Article
- Associations of technostressors at work with burnout symptoms and chronic low-grade inflammation: a cross-sectional analysis in hospital employees.International archives of occupational and environmental health · 2023Article
- ForDigitStress: presentation and evaluation of a new laboratory stressor using a digital job interview-scenario.Frontiers in psychology · 2023Article
- Within subject rise in serum TNFα to IL-10 ratio is associated with poorer attention, decision-making and working memory in jockeys.Comprehensive psychoneuroendocrinology · 2022Article
- Higher Peripheral Inflammation Is Associated With Lower Orbitofrontal Gamma Power in Chronic Tinnitus.Frontiers in behavioral neuroscience · 2022Article
- Psychosocial working conditions and chronic low-grade inflammation in geriatric care professionals: A cross-sectional study.PloS one · 2022Article
- Physiological stress in response to multitasking and work interruptions: Study protocol.PloS one · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesChronic low-grade inflammation has been identified as a key pathway linking stress experience to human health. However, systematic evaluations on the relationship of work stress and immune function are scarce and predominantly based on cross-sectional studies. We performed a systematic review and meta-analysis of prospective studies on associations of working conditions and inflammatory biomarkers.
methodsIn line with our previously established study protocol and the PRISMA-guidelines, we systematically searched electronic databases for prospective studies on working conditions as well as workplace interventions and inflammatory markers in employees. We classified studies (by design, type of exposure/intervention, outcome) and performed rigorous risk-of-bias assessments. Studies were summarized qualitatively, and a meta-analysis was conducted.
resultsWe identified 23 eligible studies (N=16 432) with a broad scope of working conditions and inflammatory markers. For interventional designs, we differentiated between individual-directed/behavioral (including physical and mental) and organization-directed/structural interventions. Workplace physical exercise interventions were associated with a decrease in C-reactive protein (k=5; d=-0.61; P<0.001). For other workplace interventions, ie, mental and organizational/structural, results were inconclusive. Concerning observational studies, dimensions of the job demand-control(-support) model were most frequently investigated, and results showed weak - if any - associations with inflammatory markers.
conclusionsThe research base was heterogeneous and high-level evidence was limited. More prospective studies are needed with broader consideration of work stressors and inflammatory markers. For practical occupational health management, exercise interventions are effective measures to reduce chronic low-grade inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.