ArticleJournal of hazardous materials2022
Desulfonation and defluorination of 6:2 fluorotelomer sulfonic acid (6:2 FTSA) by Rhodococcus jostii RHA1: Carbon and sulfur sources, enzymes, and pathways.
Article in Journal of hazardous materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
29 citing papers in PubMed, 110 citations in OpenAlex.
- Probiotic and Microbial Enzymatic Mechanisms for PFAS Detoxification.Probiotics and antimicrobial proteins · 2026Review
- Comparative Hepatotoxicity Assessment of PFOS and Its Alternative 6:2 FTSA in Adult Female Zebrafish.Animals : an open access journal from MDPI · 2026Article
- Bacteria covalently incorporate polyfluoroalkyl carboxylates into membrane lipids.Nature microbiology · 2026Article
- Current Research Advances and Future Prospects on Microbial Consortia for Sustainable PFAS Remediation.International journal of molecular sciences · 2026Review
- Biotransformation and partitioning of structurally different PFAS by wastewater microbial consortia.Environmental science : water research & technology · 2026Article
- Soil enzyme dynamics under PFAS contamination in arid and Mediterranean soils.NPJ emerging contaminants · 2026Article
- Environmental behavior and human health risks of PFAS: occurrence, toxicity, and the state-of-the-art removal approaches.RSC advances · 2025Review
- From carboxylates to chlorinated sulfonates: Contrasting fate and treatment prospects of GenX and F53B in WWTPs.The Science of the total environment · 2025Review
- Perfluoroalkane Sulfonamides and Derivatives, a Different Class of PFAS: Sorption and Microbial Biotransformation Insights.Environmental science & technology · 2025Review
- Recent advances in microbial and bioelectrochemical strategies for degradation of per- and polyfluoroalkyl substances: mechanisms, limitations, and research opportunities.Biotechnology letters · 2025Review
- Metagenome-Assembled Genomes and Metatranscriptome Analysis of Perfluorooctane Sulfonate-Reducing Bacteria Enriched From Activated Sludge.Environmental microbiology · 2025Article
- Biotransforming the "Forever Chemicals": Trends and Insights from Microbiological Studies on PFAS.Environmental science & technology · 2025Review
- Article
- Biodesulfurization enhancementHeliyon · 2025Article
- PFAS biodegradation by Labrys portucalensis F11: Evidence of chain shortening and identification of metabolites of PFOS, 6:2 FTS, and 5:3 FTCA.The Science of the total environment · 2025Article
- PFAS in water environments: recent progress and challenges in monitoring, toxicity, treatment technologies, and post-treatment toxicity.Environmental systems research · 2025Review
- Nexus of Soil Microbiomes, Genes, Classes of Carbon Substrates, and Biotransformation of Fluorotelomer-Based Precursors.Environmental science & technology · 2024Article
- Synergistic material-microbe interface toward deeper anaerobic defluorination.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Electron bifurcation and fluoride efflux systems implicated in defluorination of perfluorinated unsaturated carboxylic acids byScience advances · 2024Article
- Surface Science View of Perfluoroalkyl Acids (PFAAs) in the Environment.ACS environmental Au · 2024Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
6:2 fluorotelomer sulfonic acid (6:2 FTSA) is one per- and poly-fluoroalkyl substances commonly detected in the environment. While biotransformation of 6:2 FTSA has been reported, factors affecting desulfonation and defluorination of 6:2 FTSA remain poorly understood. This study elucidated the effects of carbon and sulfur sources on the gene expression of Rhodococcus jostii RHA1 which is responsible for the 6:2 FTSA biotransformation. While alkane monooxygenase and cytochrome P450 were highly expressed in ethanol-, 1-butanol-, and n-octane-grown RHA1 in sulfur-rich medium, these cultures only defluorinated 6:2 fluorotelomer alcohol but not 6:2 FTSA, suggesting that the sulfonate group in 6:2 FTSA hinders enzymatic defluorination. In sulfur-free growth media, alkanesulfonate monooxygenase was linked to desulfonation of 6:2 FTSA; while alkane monooxygenase, haloacid dehalogenase, and cytochrome P450 were linked to defluorination of 6:2 FTSA. The desulfonation and defluorination ability of these enzymes toward 6:2 FTSA were validated through heterologous gene expression and in vitro assays. Four degradation metabolites were confirmed and one was identified as a tentative metabolite. The results provide a new understanding of 6:2 FTSA biotransformation by RHA1. The genes encoding these desulfonating- and defluorinating-enzymes are potential markers to be used to assess 6:2 FTSA biotransformation in the environment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.