Evidence map›Paper›PMID 34523420›Full record

ArticleeLife2021

A modified fluctuation assay reveals a natural mutator phenotype that drives mutation spectrum variation within

Pengyao Jiang, Anja R Ollodart, Vidha Sudhesh, Alan J Herr, Maitreya J Dunham, Kelley Harris

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 46 citations in OpenAlex.

  1. Dynamics of mutators of arbitrary dominance in humans.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. A sibling study of variation in parental mutation rates.bioRxiv : the preprint server for biology · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Direct and indirect selection in a proofreading polymerase.bioRxiv : the preprint server for biology · 2024
    Article
  12. The Evolutionary Interplay of Somatic and Germline Mutation Rates.Annual review of biomedical data science · 2024
    Review
  13. bioRxiv : the preprint server for biology · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. "Evolution of the mutation spectrum across a mammalian phylogeny".bioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Pengyao JiangDepartment of Genome Sciences, University of Washington, Seattle, United States.
Anja R OllodartDepartment of Genome Sciences, University of Washington, Seattle, United States.
Vidha SudheshDepartment of Genome Sciences, University of Washington, Seattle, United States.
Alan J HerrDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, United States.ORCID https://orcid.org/0000-0002-9498-0972
Maitreya J DunhamDepartment of Genome Sciences, University of Washington, Seattle, United States.ORCID https://orcid.org/0000-0001-9944-2666
Kelley HarrisDepartment of Genome Sciences, University of Washington, Seattle, United States.ORCID https://orcid.org/0000-0003-0302-2523
University of Washington · USCape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZA

Funding

INTERDISCIPLINARY TRAINING IN GENOMIC SCIENCEST32HG000035 · NHGRI · UNIVERSITY OF WASHINGTON · PI Bruce Colston Trapnell · 1995 to 2026
$24.2M
TrainingP41GM103533 · NIGMS · UNIVERSITY OF WASHINGTON · PI YATES III, JOHN R · 2012 to 2021
$20.7M
Investigating the landscape and genetic architecture of germline mutagenesisR35GM133428 · NIGMS · UNIVERSITY OF WASHINGTON · PI Kelley Harris · 2019 to 2026
$2.8M
Volatility of mutator phenotypes at single cell resolutionR01GM118854 · NIGMS · UNIVERSITY OF WASHINGTON · PI KENNEDY, SCOTT ROBERT · 2016 to 2020
$1.5M
Howard Hughes Medical InstituteNHGRI NIH HHS T32 HG000035NIGMS NIH HHS P41 GM103533NIGMS NIH HHS R01 GM118854NIGMS NIH HHS R35 GM133428
6 · The paper itself

Abstract

Although studies of

Indexed as

Genetic VariationPoint MutationAllelesAmino Acid Transport Systems, BasicDiploidyDNA RepairGenetic Complementation TestHaploidyMutation RatePhenotypeSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsAmino Acid Transport Systems, BasicCAN1 protein, S cerevisiaeSaccharomyces cerevisiae Proteinsevolutionary biologygeneticsgenetic variationgenomicsmutation ratemutation spectrummutator phenotypereporter assaySaccharomyces cerevisiaeS. cerevisiae

Identifiers

PMID34523420
PMCPMC8497059
OpenAlexW3200797520

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.