Evidence map›Paper›PMID 34523247›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021

Death Pathways of Cancer Cells Modulated by Surface Molecule Density on Gold Nanorods.

Fulei Zhang, Yi Hou, Minhui Zhu, Bo Deng, Mengxin Zhao, Xiandi Zhu, Yun Sun, Di Chen, Cheng Jiang, Liming Wang and 5 more

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Safety Landscape of Therapeutic Nanozymes and Future Research Directions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Nanodrugs Detonate Lysosome Bombs.Frontiers in pharmacology · 2022
    Review
  10. Death Pathways of Cancer Cells Modulated by Surface Molecule Density on Gold Nanorods.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Fulei ZhangDepartment of Nanomedicine & International Joint Cancer Institute, Naval Medical University, Shanghai, 200433, China.
Yi HouDepartment of Nanomedicine & International Joint Cancer Institute, Naval Medical University, Shanghai, 200433, China.
Minhui ZhuDepartment of Otolaryngology Head & Neck Surgery, Shanghai Changhai Hospital, Naval Medical University, 168 Changhai Road, Shanghai, 200433, China.
Bo DengState Key Laboratory of New Textile Materials and Advanced Processing Technologies, Wuhan, 430073, China.
Mengxin ZhaoDepartment of Nanomedicine & International Joint Cancer Institute, Naval Medical University, Shanghai, 200433, China.
Xiandi ZhuDepartment of Nanomedicine & International Joint Cancer Institute, Naval Medical University, Shanghai, 200433, China.
Yun SunDepartment of Nanomedicine & International Joint Cancer Institute, Naval Medical University, Shanghai, 200433, China.
Di ChenDepartment of Nanomedicine & International Joint Cancer Institute, Naval Medical University, Shanghai, 200433, China.
Cheng JiangDepartment of Nanomedicine & International Joint Cancer Institute, Naval Medical University, Shanghai, 200433, China.
Liming WangCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics and National Center for Nanoscience and Technology of China, Chinese Academy of Sciences, Beijing, 100049, China.
Chunying ChenCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics and National Center for Nanoscience and Technology of China, Chinese Academy of Sciences, Beijing, 100049, China.
Huaiwen ChenDepartment of Otolaryngology Head & Neck Surgery, Shanghai Changhai Hospital, Naval Medical University, 168 Changhai Road, Shanghai, 200433, China.
Han ChenDepartment of General Surgery, Navy No.905 Hospital of Chinese People's Liberation Army, Naval Medical University, Shanghai, 200050, China.
Hongliang ZhengDepartment of Otolaryngology Head & Neck Surgery, Shanghai Changhai Hospital, Naval Medical University, 168 Changhai Road, Shanghai, 200433, China.
Wei LiDepartment of Nanomedicine & International Joint Cancer Institute, Naval Medical University, Shanghai, 200433, China.ORCID 0000-0002-7999-6570
Shanghai International Medical Center · CNSecond Military Medical University · CNChinese Academy of Sciences · CNWuhan Textile University · CN

Funding

National Natural Science Foundation of China 31470964National Natural Science Foundation of China 81772881National Natural Science Foundation of China 81970868National Natural Science Foundation of China 81972271
6 · The paper itself

Abstract

Necrosis induces strong inflammation with undesirable implications in clinics compared with apoptosis. Fortunately, the switch between necrosis and apoptosis could be realized by tailoring the appropriate structural properties of gold nano rods (GNRs) that could precisely modulate cell death pathways. Herein, the intracellular interaction between GNRs and organelles is monitored and it is found that lysosomes dominates necrosis/apoptosis evoking. Then the surface molecule density of GNRs, which is first defined as ρ

Indexed as

ApoptosisAnimalsCell Line, TumorDisease Models, AnimalGoldHumansMiceMice, NudeNanotubesNecrosisNeoplasmsGoldcancer therapycell death pathwaygold nanorodssurface molecule density

Identifiers

PMID34523247
PMCPMC8596106
OpenAlexW3199890547

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.