Evidence map›Paper›PMID 34523025›Full record

ArticlePediatric cardiology2022

Calcium Chloride Infusions are Not Associated with Improved Outcomes in Neonates Undergoing Cardiac Operations.

Laura E Murray, Holly Burchett, Shahryar M Chowdhury, A Lauren Haney, Marc Hassid, Jacob R Strelow, Eric M Graham, Minoo N Kavarana, Jason R Buckley

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Laura E MurrayDepartment of Pediatrics, Medical University of South Carolina, 10 McClennan Banks Drive, Charleston, SC, 29425, USA.
Holly BurchettDepartment of Pediatrics, Medical University of South Carolina, 10 McClennan Banks Drive, Charleston, SC, 29425, USA.
Shahryar M ChowdhuryDepartment of Pediatrics, Medical University of South Carolina, 10 McClennan Banks Drive, Charleston, SC, 29425, USA.
A Lauren HaneyDepartment of Clinical Pharmacy and Outcome Science, Medical University of South Carolina, Charleston, SC, 29425, USA.
Marc HassidDepartment of Anesthesia and Perioperative Medicine, Medical University of South Carolina, Charleston, SC, 29425, USA.
Jacob R StrelowTexas Center for Pediatric and Congenital Heart Disease, UT Health Austin and Dell Children's Medical Center, Dell Medical School of the University of Texas at Austin, Austin, TX, 78712, USA.
Eric M GrahamDepartment of Pediatrics, Medical University of South Carolina, 10 McClennan Banks Drive, Charleston, SC, 29425, USA.
Minoo N KavaranaDepartment of Surgery, Medical University of South Carolina, Charleston, SC, 29425, USA.
Jason R BuckleyDepartment of Pediatrics, Medical University of South Carolina, 10 McClennan Banks Drive, Charleston, SC, 29425, USA. buckleyj@musc.edu.ORCID http://orcid.org/0000-0002-9920-6425
Medical University of South Carolina · USDell Children's Medical Center of Central Texas · US

Funding

Heart Failure in Single Right Ventricle Physiology: Pathologic Mechanisms and Novel AssessmentK23HL133447 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI CHOWDHURY, SHAHRYAR M. · 2017 to 2021
$1.0M
NHLBI NIH HHS K23 HL133447
6 · The paper itself

Abstract

Neonatal cardiac performance is dependent on calcium delivery to the myocardium. Little is known about the use and impact of calcium chloride infusions in neonates who undergo cardiac surgery. We hypothesized that the use of calcium chloride infusions would decrease the doses required of traditional inotropic and vasoactive medications by supporting cardiac output in this patient population. We performed a single-institution, retrospective, cohort study. All neonates (≤ 30 days old) undergoing cardiac surgery from 06/01/2015 through 12/31/2018 were included. Patients were divided into two groups: those who received postoperative calcium chloride infusions (calcium group) and those who did not (control group). The primary outcome was the occurrence of a maximum Vasoactive Inotropic Score (VIS) > 15 in the first 24 h following surgery. One hundred and thirty-five patients met inclusion criteria. Sixty-six patients received postoperative calcium infusions and 69 patients did not. Gestational age, weight at surgery, age at surgery, surgical complexity and cardiopulmonary bypass times were similar between groups. Forty-two (70%) patients receiving calcium had a postoperative maximum VIS > 15 compared with 38 (55%) patients not on a calcium infusion (p = 0.08). There were no differences in postoperative length of ventilation, time to enteral feeding, hospital LOS, or operative mortality between groups. Calcium chloride infusions in neonates who underwent cardiac surgery did not decrease exposure to other inotropic and vasoactive agents in the first 24 post-operative hours or improve patient outcomes.

Indexed as

Cardiac Surgical ProceduresHeart Defects, CongenitalCalcium ChlorideCardiopulmonary BypassCohort StudiesHumansInfant, NewbornPostoperative PeriodRetrospective StudiesCalcium ChlorideCalciumCongenital heart diseaseCongenital heart surgeryIntensive careNeonateOutcomes

Identifiers

PMID34523025
PMCPMC9462392
OpenAlexW3199931919

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.