Evidence map›Paper›PMID 34522857›Full record

ArticleiScience2021

A resource of high-quality and versatile nanobodies for drug delivery.

Zhuolun Shen, Yufei Xiang, Sandra Vergara, Apeng Chen, Zhengyun Xiao, Ulises Santiago, Changzhong Jin, Zhe Sang, Jiadi Luo, Kong Chen and 5 more

Abstract read
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Single-Domain Antibodies-Novel Tools to Study and Treat Allergies.International journal of molecular sciences · 2024
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. EnhancedbioRxiv : the preprint server for biology · 2023
    Article
  13. Article
  14. Nanobodies: Robust miniprotein binders in biomedicine.Advanced drug delivery reviews · 2023
    Review
  15. Article
  16. Nanobodies as a powerful platform for biomedicine.Trends in molecular medicine · 2022
    Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Zhuolun ShenDepartment of Cell Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Yufei XiangDepartment of Cell Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Sandra VergaraDepartment of Structural Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Apeng ChenDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Zhengyun XiaoDepartment of Cell Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Ulises SantiagoDepartment of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Changzhong JinDepartment of Cell Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Zhe SangDepartment of Cell Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Jiadi LuoDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Kong ChenDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Dina Schneidman-DuhovnySchool of Computer Science and Engineering, Institute of Life Sciences, University of Jerusalem, Tambaram, Israel.
Carlos CamachoDepartment of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Guillermo CaleroDepartment of Structural Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Baoli HuDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Yi ShiDepartment of Cell Biology, University of Pittsburgh, Pittsburgh, PA, USA.

Funding

Mapping the Dynamic Interactome of Ig-fold Membrane Proteins Using Nanobody-Based ToolsR35GM137905 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Yi Shi · 2020 to 2026
$2.8M
Real-time discovery of inhibitors among billion compounds for preview and downloadR01GM097082 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CAMACHO, CARLOS J. · 2011 to 2020
$2.5M
Epigenetic regulation of chemokines in lung inflammationR01HL137709 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, KONG · 2018 to 2021
$1.6M
NHLBI NIH HHS R01 HL137709NIGMS NIH HHS R01 GM097082NIGMS NIH HHS R35 GM137905
6 · The paper itself

Abstract

Therapeutic and diagnostic efficacies of small biomolecules and chemical compounds are hampered by suboptimal pharmacokinetics. Here, we developed a repertoire of robust and high-affinity antihuman serum albumin nanobodies (Nb

Indexed as

Biochemical EngineeringBiotechnologyDrug Delivery SystemProteomicsStructural Biology

Identifiers

PMID34522857
PMCPMC8426283

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.