Evidence map›Paper›PMID 34522629›Full record

ArticleAfrican journal of laboratory medicine2021

Strategic site selection for placement of HIV early infant diagnosis point-of-care technology within a national diagnostic network in Lesotho.

Anafi Mataka, Esther A J Tumbare, Tsietso Motsoane, David Holtzman, Monkoe Leqheka, Kolisang Phatsoane, Emma Sacks, Anthony Isavwa, Appolinaire Tiam

Open access · diamondAbstract read
In one paragraph

Article in African journal of laboratory medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 4 countries.

Anafi MatakaAfrican Society for Laboratory Medicine, Addis Ababa, Ethiopia.ORCID https://orcid.org/0000-0002-9888-4064
Esther A J TumbareElizabeth Glaser Pediatric AIDS Foundation (EGPAF), Maseru, Lesotho.ORCID https://orcid.org/0000-0002-4140-7101
Tsietso MotsoaneLaboratory Services, Ministry of Health, Maseru, Lesotho.ORCID https://orcid.org/0000-0001-7246-2587
David HoltzmanPartners in Health, Maseru, Lesotho.ORCID https://orcid.org/0000-0001-9214-5685
Monkoe LeqhekaLaboratory Services, Ministry of Health, Maseru, Lesotho.ORCID https://orcid.org/0000-0003-0509-4715
Kolisang PhatsoaneLaboratory Services, Ministry of Health, Maseru, Lesotho.ORCID https://orcid.org/0000-0001-9766-2390
Emma SacksSchool of Public Health, George Washington University, Washington, District of Columbia, United States.ORCID https://orcid.org/0000-0003-0743-7208
Anthony IsavwaElizabeth Glaser Pediatric AIDS Foundation (EGPAF), Nairobi, Kenya.ORCID https://orcid.org/0000-0002-5941-2478
Appolinaire TiamElizabeth Glaser Pediatric AIDS Foundation (EGPAF), Washington, District of Columbia, United States.ORCID https://orcid.org/0000-0002-8045-7590
Ministry of Health · LSElizabeth Glaser Pediatric AIDS Foundation · USAfrica Mental Health Foundation · KEAfrican Society for Laboratory Medicine · ETGeorge Washington University · USPartners In Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNew technologies for rapid point-of-care (POC) diagnostic tests hold great potential for improving the health outcomes of HIV-exposed infants. POC testing for HIV early infant diagnosis (EID) was introduced in Lesotho in late 2016. Here we highlight critical requirements for selecting routine POC EID sites to ensure a sustainable and optimised EID diagnostic network.

interventionLesotho introduced POC EID in a phased approach that included assessments of national databases to identify sites with high test volumes, the creation of local networks of sites to potentially increase access to POC EID, and a standardised capacity assessment to determine site readiness. Potential site networks comprising 'hub' testing sites and 'spoke' specimen referring sites were created. LESSONS LEARNT: After determining optimal placement, a total of 29 testing facilities were selected for placement of POC EID to potentially increase access to 189 facilities through the use of a hub-and-spoke model. Site capacity assessments identified vital human resources and infrastructure capacity gaps that needed to be addressed before introducing POC EID and informed appropriate POC platform selection. RECOMMENDATIONS: POC placement involves more than just purchasing the testing platforms. Considering the relatively small proportion of sites that can be eligible for placement of a POC platform, utilising a hub-and-spoke model can maximise the number of health facilities served by a POC platform while reducing the necessary capacity building and infrastructure investments to fewer sites.

Indexed as

HIV early infant diagnosisincreased health accesspoint-of-caresite selection

Identifiers

PMID34522629
PMCPMC8424766
OpenAlexW3193486957

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.