ArticlePhotoacoustics2021
Detection of collagen by multi-wavelength photoacoustic analysis as a biomarker for bone health assessment.
Article in Photoacoustics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 33 citations in OpenAlex.
- Tumor survivors' musculoskeletal health assessment: advances in imaging biomarkers for cancer treatment-related sequelae.Journal of orthopaedic surgery and research · 2026Review
- Spectral photoacoustic imaging of age-related reproductive tract collagen changes in a mouse model of prolapse.Photoacoustics · 2026Article
- Advances in photoacoustic imaging reconstruction and quantitative analysis for biomedical applications.Visual computing for industry, biomedicine, and art · 2026Review
- High spectral energy density all-fiber nanosecond pulsed 1.7 μm light source for photoacoustic microscopy.Photoacoustics · 2025Article
- Detecting Collagen by Machine Learning Improved Photoacoustic Spectral Analysis for Breast Cancer Diagnostics: Feasibility Studies With Murine Models.Journal of biophotonics · 2025Article
- Assessing Breast Cancer through Tumor Microenvironment Mapping of Collagen and Other Biomolecule Spectral Fingerprints─A Review.ACS sensors · 2024Review
- Feasibility study on the introduction of Micro-CT technology for the identification ofFrontiers in pharmacology · 2024Article
- Theoretical and experimental study of attenuation in cancellous bone.Journal of biomedical optics · 2024Article
- 4D spectral-spatial computational photoacoustic dermoscopy.Photoacoustics · 2023Article
- Identification of different types of tumors based on photoacoustic spectral analysis: preclinical feasibility studies on skin tumors.Journal of biomedical optics · 2023Article
- Molecular breast cancer subtype identification using photoacoustic spectral analysis and machine learning at the biomacromolecular level.Photoacoustics · 2023Article
- Altered type I collagen networking in osteoporotic human femoral head revealed by histomorphometric and Fourier transform infrared imaging correlated analyses.BioFactors (Oxford, England) · 2022Article
- Bone hydration: How we can evaluate it, what can it tell us, and is it an effective therapeutic target?Bone reports · 2022Article
- Myocardial infarct border demarcation by dual-wavelength photoacoustic spectral analysis.Photoacoustics · 2022Article
- Characterization of multi-biomarkers for bone health assessment based on photoacoustic physicochemical analysis method.Photoacoustics · 2022Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Collagen is an important biomarker of osteoporosis progression. Noninvasive, multispectral, photoacoustic (PA) techniques use pulsed laser light to induce PA signals to facilitate the visualization of chemical components that are strongly related to tissue health. In this study, the feasibility of multi-wavelength PA (MWPA) measurement of the collagen in bone, using the wavelength range of 1300-1800 nm, was investigated. First, the feasibility of this approach for detecting the collagen content of bone was demonstrated by means of numerical simulation. Then, ex vivo experiments were conducted on both animal and human bone specimens with different bone densities using the MWPA method. The relative collagen content was extracted and compared with the results of micro-computed tomography (micro-CT) and histology. The results showed that the "relative collagen content" parameter obtained using the MWPA approach correlated well with the bone volume ratio obtained from micro-CT images and histological analysis results. This study highlights the potential of the proposed PA technique for determining the collagen content of bones as a biomarker for bone health assessment.
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