Evidence map›Paper›PMID 34522502›Full record

ReviewCureus2021

Kikuchi-Fujimoto Disease: A Rare Cause of Cervical Lymphadenopathy.

Zubayer Ahmed, Huma Quadir, Knkush Hakobyan, Mrunanjali Gaddam, Amudhan Kannan, Ugochi Ojinnaka, Jihan A Mostafa

Open access · diamondAbstract readReview
In one paragraph

Review in Cureus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
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  12. Kikuchi-Fujimoto disease, case report.Oxford medical case reports · 2025
    Article
  13. Article
  14. Article
  15. Kikuchi-Fujimoto Disease: A Rare Condition Mimicking Sepsis.Iranian journal of otorhinolaryngology · 2025
    Article
  16. Article
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  18. Article
  19. Kikuchi-Fujimoto Disease: a rare type of lymphadenopathy and its plausible relationship with human papillomavirus vaccines.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Zubayer AhmedInternal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Huma QuadirInternal Medicine/Family Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Knkush HakobyanDiagnostic Radiology, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Mrunanjali GaddamInternal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Amudhan KannanGeneral Surgery, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Ugochi OjinnakaFamily Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Jihan A MostafaPsychiatry, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
California Institute of Behavioral Neurosciences and Psychology (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kikuchi-Fujimoto disease (KFD) is a rare benign disease, clinically characterized by fever and tender cervical lymphadenopathy affecting the posterior cervical lymph nodes. This disease is usually accompanied by night sweats, rashes, and headaches. It generally affects young individuals, especially females, of Oriental-Asian origin. The etiology of KFD remains uncertain, but associations have been noted with viral diseases including Epstein-Barr virus (EBV), herpes simplex virus (HSV), and varicella-zoster virus (VZV), as well as autoimmune disorders including systemic lupus erythematosus (SLE) and Sjogren's syndrome. This review points out the etiology of KFD with cervical lymphadenopathy alongside its clinical presentation, histological highlights, lab investigations, complications, and treatment. Accurate diagnosis of this disease depends on lymph node excisional biopsy. Three histological patterns of KFD are recognized: proliferative, necrotizing, and xanthomatous. Distinction from lymphadenopathy-associated alternate disorders (e.g., SLE, malignancy, tuberculosis, or another infectious lymphadenitis) is essential to ensure appropriate therapy. This self-limited condition entails nonsteroidal anti-inflammatory drugs (NSAIDs) for pain relief with consideration of corticosteroids and hydroxychloroquine in severe cases.

Indexed as

autoimmune diseasesimmunohistochemistrykikuchi-fujimoto diseaselymphadenopathyviral infection

Identifiers

PMID34522502
PMCPMC8425500
OpenAlexW3191588781

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.