Evidence map›Paper›PMID 34522457›Full record

ArticleAmerican journal of cancer research2021

MiR-374b-5p inhibits KDM5B-induced epithelial-mesenchymal transition in pancreatic cancer.

Xin Zhao, Xiaoshi Zhang, Xinxue Zhang, Tao Jiang, Jialei Zhai, Huaguang Wang, Mengxiu Huang, Ren Lang, Qiang He

Open access · greenAbstract read
In one paragraph

Article in American journal of cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 13 citations in OpenAlex.

  1. International journal of molecular sciences · 2026
    Article
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  9. miRNAs in pancreatic cancer progression and metastasis.Clinical & experimental metastasis · 2024
    Review
  10. Review
  11. Article
  12. Article
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  14. HumanInternational journal of biological sciences · 2022
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Xin ZhaoDepartment of Hepatobiliary Surgery, Beijing Chao-Yang Hospital, Affiliated to Capital Medical University Beijing, China.
Xiaoshi ZhangDepartment of Hepatobiliary Surgery, Beijing Chao-Yang Hospital, Affiliated to Capital Medical University Beijing, China.
Xinxue ZhangDepartment of Hepatobiliary Surgery, Beijing Chao-Yang Hospital, Affiliated to Capital Medical University Beijing, China.
Tao JiangDepartment of Hepatobiliary Surgery, Beijing Chao-Yang Hospital, Affiliated to Capital Medical University Beijing, China.
Jialei ZhaiDepartment of Hepatobiliary Surgery, Beijing Chao-Yang Hospital, Affiliated to Capital Medical University Beijing, China.
Huaguang WangDepartment of Hepatobiliary Surgery, Beijing Chao-Yang Hospital, Affiliated to Capital Medical University Beijing, China.
Mengxiu HuangDepartment of Hepatobiliary Surgery, Beijing Chao-Yang Hospital, Affiliated to Capital Medical University Beijing, China.
Ren LangDepartment of Hepatobiliary Surgery, Beijing Chao-Yang Hospital, Affiliated to Capital Medical University Beijing, China.
Qiang HeDepartment of Hepatobiliary Surgery, Beijing Chao-Yang Hospital, Affiliated to Capital Medical University Beijing, China.
Beijing Chao-Yang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Micro(mi)RNAs play a critical regulatory role in the progression and metastasis of pancreatic cancer (PC). In this study, we aimed to reveal the mechanisms of miR-374b-5p in regulating epithelial-mesenchymal transition (EMT) in PC. Gene Expression Omnibus datasets (GSE24279 and GSE71533) and the pancreatic ductal adenocarcinoma (PDAC) cohort of The Cancer Genome Atlas were employed to screen for potential prognostic miRNAs. The expression of miR-374b-5p was measured by quantitative real-time polymerase chain reaction (qRT-PCR) in 78 paired PDAC tissue samples. The biological effects of miR-374b-5p were investigated using

Indexed as

epithelial-mesenchymal transitionKDM5BmiR-374b-5ppancreatic cancer

Identifiers

PMID34522457
PMCPMC8414380
OpenAlexW3201235796

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.