Evidence map›Paper›PMID 34522273›Full record

ArticleArchives of medical science : AMS2021

Effect of atorvastatin on delirium status of patients in the intensive care unit: a randomized controlled trial.

Seyed Mojtaba Sohrevardi, Fatemeh Shojaei Nasab, Mohammad Reza Mirjalili, Mohammad Bagherniya, Arefeh Dehghani Tafti, Mohammad Hossein Jarrahzadeh, Mahmoud Reza Azarpazhooh, Mohsen Saeidmanesh, Maciej Banach, Tannaz Jamialahmadi and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of medical science : AMS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 8 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 8 syntheses or guidelines pooled it, 60 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Seyed Mojtaba SohrevardiDepartment of Clinical Pharmacy, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Fatemeh Shojaei NasabPharmaceutical Sciences Research Center, Faculty of Pharmacy, Shahid Sadoughi University of Medical Silences, Yazd, Iran.
Mohammad Reza MirjaliliDepartment of Anesthesia and Intensive Care Medicine, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mohammad BagherniyaDepartment of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Arefeh Dehghani TaftiDepartment of Biostatistics and Epidemiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mohammad Hossein JarrahzadehDepartment of Anesthesia and Intensive Care Medicine, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mahmoud Reza AzarpazhoohDepartment of Clinical Neurological Sciences, University of Western Ontario, Canada.
Mohsen SaeidmaneshDepartment of Psychology, Science and Arts University, Yazd, Iran.
Maciej BanachDepartment of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz, Lodz, Poland.
Tannaz JamialahmadiHalal Research Center of IRI, FDA, Tehran, Iran.
Amirhossein SahebkarBiotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Shahid Sadoughi University of Medical Sciences and Health Services · IRMashhad University of Medical Sciences · IRWestern University · CAIsfahan University of Medical Sciences · IRPolish Mother’s Memorial Hospital Research Institute · PLYazd University · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDelirium is one of the most prevalent complications in intensive care unit (ICU) patients, which is related to worse clinical outcomes including a longer ICU stay, longer duration of mechanical ventilation, higher mortality rates and increased risk of cognitive impairment. Observational studies have suggested that statins might have a positive effect on delirium status of hospitalized patients. To date, there has been no trial assessing the effect of atorvastatin on delirium status in critically ill patients. Thus, the aim of the current study was to determine the efficacy of atorvastatin on delirium status of patients in the ICU.

methodsIn this randomized, double-blind and controlled trial, a total of 90 patients in the general ICU who had delirium for at least 2 days were randomly divided into atorvastatin (40 mg/day) (

resultsAdministration 40 mg/day of atorvastatin significantly reduced the mean RASS score and increased delirium-free days at both morning and afternoon time points compared to the control group (

conclusionsAdministration of atorvastatin had a significant positive effect on delirium status in patients admitted to the ICU.

Indexed as

atorvastatinC-reactive proteindeliriumintensive care unitstatins

Identifiers

PMID34522273
PMCPMC8425261
OpenAlexW2990008797

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.