Evidence map›Paper›PMID 34522223›Full record

ArticleTheranostics2021

Activation of Hippo signaling pathway mediates mitochondria dysfunction and dilated cardiomyopathy in mice.

Wei Wu, Mark Ziemann, Kevin Huynh, Gang She, Zheng-Da Pang, Yi Zhang, Thy Duong, Helen Kiriazis, Tian-Tian Pu, Ru-Yue Bai and 7 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
6.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 91 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Mitochondrial Adaptation to Mechanical Stress in Cardiac Ageing and Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Environment & health (Washington, D.C.) · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Mitochondrial Dysfunction in HFpEF: Potential Interventions Through Exercise.Journal of cardiovascular translational research · 2025
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Heart failure, inflammation and exercise.International journal of biological sciences · 2025
    Review
  20. Regulatory mechanisms of mAmerican journal of translational research · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Wei WuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xian Jiaotong University Health Science Center, Xian, China.
Mark ZiemannSchool of Life and Environmental Sciences, Deakin University, Geelong, Victoria, Australia.
Kevin HuynhBaker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Gang SheDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xian Jiaotong University Health Science Center, Xian, China.
Zheng-Da PangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xian Jiaotong University Health Science Center, Xian, China.
Yi ZhangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xian Jiaotong University Health Science Center, Xian, China.
Thy DuongBaker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Helen KiriazisBaker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Tian-Tian PuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xian Jiaotong University Health Science Center, Xian, China.
Ru-Yue BaiDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xian Jiaotong University Health Science Center, Xian, China.
Jing-Jing LiDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xian Jiaotong University Health Science Center, Xian, China.
Yu ZhangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xian Jiaotong University Health Science Center, Xian, China.
Ming-Xia ChenCenter of Electron Microscopy, Xian Jiaotong University Health Science Center, Xian, China.
Junichi SadoshimaNew Jersey Medical School, Department of Cell Biology and Molecular Medicine Rutgers, New Jersey, United States of America.
Xiu-Ling DengDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xian Jiaotong University Health Science Center, Xian, China.
Peter J MeikleBaker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Xiao-Jun DuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xian Jiaotong University Health Science Center, Xian, China.
Baker Heart and Diabetes Institute · AUDeakin University · AURutgers New Jersey Medical School

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Adaptor Proteins, Signal TransducingAnimalsCardiomyopathiesCardiomyopathy, DilatedChinaHippo Signaling PathwayHumansMaleMiceMice, TransgenicMitochondriaMyocytes, CardiacSignal TransductionTranscription FactorsAdaptor Proteins, Signal TransducingTranscription Factorsdilated cardiomyopathyheart failureHippo pathwaymitochondriatranscriptome analysis

Identifiers

PMID34522223
PMCPMC8419046
OpenAlexW3196991967

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.