Evidence map›Paper›PMID 34522160›Full record

ArticleInternational journal of medical sciences2021

Cellular and Tissue Selectivity of AAV Serotypes for Gene Delivery to Chondrocytes and Cartilage.

Dong Suk Yoon, Kyoung-Mi Lee, Sehee Cho, Eun Ae Ko, Jihyun Kim, Sujin Jung, Jae-Hyuck Shim, Guangping Gao, Kwang Hwan Park, Jin Woo Lee

Open access · goldAbstract read
In one paragraph

Article in International journal of medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Harnessing CRISPR potential for intervertebral disc regeneration strategies.Frontiers in bioengineering and biotechnology · 2025
    Review
  5. Article
  6. Review
  7. Rationally engineered novel AAV capsids for intra-articular gene delivery.Molecular therapy. Methods & clinical development · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Dong Suk YoonDepartment of Orthopedic Surgery, Yonsei University College of Medicine, Seoul 03722, South Korea.
Kyoung-Mi LeeDepartment of Orthopedic Surgery, Yonsei University College of Medicine, Seoul 03722, South Korea.
Sehee ChoDepartment of Orthopedic Surgery, Yonsei University College of Medicine, Seoul 03722, South Korea.
Eun Ae KoDepartment of Orthopedic Surgery, Yonsei University College of Medicine, Seoul 03722, South Korea.
Jihyun KimDepartment of Orthopedic Surgery, Yonsei University College of Medicine, Seoul 03722, South Korea.
Sujin JungDepartment of Orthopedic Surgery, Yonsei University College of Medicine, Seoul 03722, South Korea.
Jae-Hyuck ShimDivision of Rheumatology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Guangping GaoLi Weibo Institute for Rare Diseases Research, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Kwang Hwan ParkDepartment of Orthopedic Surgery, Yonsei University College of Medicine, Seoul 03722, South Korea.
Jin Woo LeeDepartment of Orthopedic Surgery, Yonsei University College of Medicine, Seoul 03722, South Korea.
Yonsei University · KRUniversity of Massachusetts Chan Medical School · US

Funding

Viral escape from AAV expressed transgenesP01AI100263 · NIAID · SCRIPPS FLORIDA · PI GAO, GUANGPING · 2012 to 2016
$11.9M
Tech-CoreP01HD080642 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QUINZII, CATARINA M. · 2014 to 2018
$7.8M
Oligodendrocyte-focused rAAV gene therapy strategies for Canavan disease and LeukodystrophiesR01NS076991 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Guangping Gao · 2012 to 2026
$5.7M
Identification of novel regulators governing osteoclast-osteoblast couplingR01AR068983 · NIAMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI SHIM, JAE-HYUCK · 2016 to 2020
$1.9M
A novel bone-targeting AAV-mediated gene therapy to promote bone formation in osteoporosisR21AR077557 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SHIM, JAE-HYUCK · 2021 to 2022
$403k
NIAID NIH HHS P01 AI100263NIAMS NIH HHS R01 AR068983NIAMS NIH HHS R21 AR077557NICHD NIH HHS P01 HD080642NINDS NIH HHS R01 NS076991
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsCartilage, ArticularChondrocytesDependovirusDisease Models, AnimalGene ExpressionGenetic TherapyGene Transfer TechniquesGreen Fluorescent ProteinsHumansMiceOsteoarthritisSerogroupTransduction, GeneticGreen Fluorescent ProteinsAdeno-associated virus (AAV) serotypesChondrocytesGene therapyOsteoarthritis

Identifiers

PMID34522160
PMCPMC8436087
OpenAlexW3188972036

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.