ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2021
The Association of Aspartate Aminotransferase/Alanine Aminotransferase Ratio with Diabetic Nephropathy in Patients with Type 2 Diabetes.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk factors for diabetic kidney disease in type 2 diabetes mellitus in Asia: a meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Remnant cholesterol/high-density lipoprotein cholesterol ratio is a new powerful tool for identifying diabetic kidney disease.Journal of diabetes investigation · 2026Article
- Development and validation of an explainable neural network model for predicting progression in type 2 diabetic kidney disease.Frontiers in endocrinology · 2026Article
- Association of triglyceride-glucose index with diabetic kidney disease in patients with type 2 diabetes.Journal of diabetes and metabolic disorders · 2025Article
- Development and external validation of a machine learning-based predictive model for acute kidney injury in hospitalized children with idiopathic nephrotic syndrome.BMC medical informatics and decision making · 2025Article
- Preclinical Evaluation of 2-Aminobenzothiazole Derivatives: In Silico, In Vitro, and Preliminary In Vivo Studies as Diabetic Treatments and Their Complications.Molecules (Basel, Switzerland) · 2025Article
- Prognostic Value of the AST/ALT Ratio in Patients with Septic Shock: A Prospective, Multicenter, Registry-Based Observational Study.Diagnostics (Basel, Switzerland) · 2025Article
- Nonlinear association between AST/ALT ratio and 28-day all-cause mortality following ICU admission in critically ill cirrhotic patients: a retrospective cohort study.BMC gastroenterology · 2025Article
- The Association Between Aspartate Transaminase to Alanine Transaminase Ratio and Perioperative Ischemic Stroke in Patients With Diabetes: A Retrospective Cohort Study.CNS neuroscience & therapeutics · 2025Article
- Association Between GGT/HDL-C Ratio and Diabetic Kidney Disease in Patients with Type-2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- The Clinical Value of the AST-to-ALT Ratio in Predicting Severity, Complications, and Prognosis in Acute Pancreatitis.Gastroenterology research and practice · 2025Article
- Article
- The ratio of high aspartate aminotransferase to alanine aminotransferase: an independent risk factor associated with poor prognosis in IgA nephropathy.Clinical and experimental nephrology · 2024Article
- Relationship of thyroid parameters with chronic inflammation in patients with euthyroid type 2 diabetes.Frontiers in endocrinology · 2024Article
- Association between AST/ALT ratio and diabetic retinopathy risk in type 2 diabetes: a cross-sectional investigation.Frontiers in endocrinology · 2024Article
- The relationship between serum γ-glutamyltransferase (GGT) and diabetic nephropathy in patients with type 2 diabetes mellitus: a cross-sectional study.Clinical and experimental medicine · 2023Article
- Enrichr-KG: bridging enrichment analysis across multiple libraries.Nucleic acids research · 2023Article
- Biomarkers of Response to Low-Dose Aspirin in Familial Adenomatous Polyposis Patients.Cancers · 2023Article
- Article
- Aspartate aminotransferase/alanine aminotransferase ratio was associated with type 2 diabetic peripheral neuropathy in a Chinese population: A cross-sectional study.Frontiers in endocrinology · 2023Article
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Authors and funding
3 authors.
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Abstract
purposeTo investigate the relationship between aspartate aminotransferase to alanine aminotransferase ratio (AST/ALT) and diabetic nephropathy (DN). PATIENTS AND
methodsA total of 402 patients with type 2 diabetes mellitus were divided into three groups, such as normoalbuminuria (n = 196), microalbuminuria (n = 131) and macroalbuminuria (n = 75) groups. Basic information and laboratory results were collected. Serum AST/ALT, tumor necrosis factor-α (TNF-α), interleukin (IL)-2, IL-4, IL-6, IL-10 and interferon- γ (INF- γ) were also measured. DN was defined as microalbuminuria or macroalbuminuria. The estimated glomerular filtration rate (eGFR) was calculated using the following formula: 186 × (serum creatinine)
resultsThe AST/ALT in the macroalbuminuria group was higher than in the microalbuminuria and normoalbuminuria groups. The concentrations of tumor necrosis factor-α (TNF-α), IL-2, IL-4, IL-10 and INF-γ in the macroalbuminuria group were significantly higher than those in the two other groups. Multivariate logistical analysis showed that after adjusting confounding factors, TNF-α and high AST/ALT were independent risks for DN and macroalbuminuria. Furthermore, the AST/ALT had significantly positive correlation with TNF-α (r = 0.101, P = 0.048), IL-4 (r = 0.185, P = 0.005) and IL-6 (r = 0.274, P < 0.001) levels.
conclusionThis study showed that high AST/ALT was an independent risk factor for the DN. Additionally, AST/ALT was positively correlated with inflammation cytokines, such as TNF-α, IL-4 and IL-6 levels.
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