Evidence map›Paper›PMID 34522049›Full record

ReviewNature reviews. Microbiology2022

Towards an integrative view of virus phenotypes.

John P DeLong, Maitham A Al-Sammak, Zeina T Al-Ameeli, David D Dunigan, Kyle F Edwards, Jeffry J Fuhrmann, Jason P Gleghorn, Hanqun Li, Kona Haramoto, Amelia O Harrison and 10 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Why did some viruses evolve to be giants while others did not?Proceedings of the National Academy of Sciences of the United States of America · 2026
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  16. Annotation Vocabulary (Might Be) All You Need.bioRxiv : the preprint server for biology · 2024
    Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

John P DeLongSchool of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE, USA. jpdelong@unl.edu.
Maitham A Al-SammakTropical Biological Research Unit, College of Science, University of Baghdad, Baghdad, Iraq.ORCID 0000-0001-6819-7143
Zeina T Al-AmeeliNebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE, USA.
David D DuniganNebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE, USA.ORCID 0000-0001-9496-5396
Kyle F EdwardsDepartment of Oceanography, University of Hawai'i at Mānoa, Honolulu, HI, USA.
Jeffry J FuhrmannDepartment of Plant and Soil Sciences, University of Delaware, Newark, DE, USA.
Jason P GleghornDepartment of Biological Sciences, University of Delaware, Newark, DE, USA.ORCID 0000-0003-1283-2966
Hanqun LiDepartment of Biological Sciences, University of Delaware, Newark, DE, USA.
Kona HaramotoDepartment of Plant and Soil Sciences, University of Delaware, Newark, DE, USA.
Amelia O HarrisonDepartment of Plant and Soil Sciences, University of Delaware, Newark, DE, USA.ORCID 0000-0001-7387-1374
Marcia F MarstonDepartment of Biology and Marine Biology, Roger Williams University, Bristol, RI, USA.ORCID 0000-0003-0387-5796
Ryan M MooreDelaware Biotechnology Institute, University of Delaware, Newark, DE, USA.ORCID 0000-0003-3337-8184
Shawn W PolsonDepartment of Plant and Soil Sciences, University of Delaware, Newark, DE, USA.
Barbra D FerrellDelaware Biotechnology Institute, University of Delaware, Newark, DE, USA.
Miranda E SalsberySchool of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE, USA.
Christopher R SchvarczDepartment of Oceanography, University of Hawai'i at Mānoa, Honolulu, HI, USA.ORCID 0000-0003-3789-2033
Jasmine ShiraziDepartment of Biomedical Engineering, University of Delaware, Newark, DE, USA.ORCID 0000-0001-8136-6589
Grieg F StewardDepartment of Oceanography, University of Hawai'i at Mānoa, Honolulu, HI, USA.ORCID 0000-0001-5988-0522
James L Van EttenNebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE, USA.
K Eric WommackDepartment of Plant and Soil Sciences, University of Delaware, Newark, DE, USA. wommack@dbi.udel.edu.ORCID 0000-0001-5797-7128

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI MELINDA K DUNCAN · 2012 to 2026
$67.2M
NIGMS NIH HHS P20 GM103446
6 · The paper itself

Abstract

Understanding how phenotypes emerge from genotypes is a foundational goal in biology. As challenging as this task is when considering cellular life, it is further complicated in the case of viruses. During replication, a virus as a discrete entity (the virion) disappears and manifests itself as a metabolic amalgam between the virus and the host (the virocell). Identifying traits that unambiguously constitute a virus's phenotype is straightforward for the virion, less so for the virocell. Here, we present a framework for categorizing virus phenotypes that encompasses both virion and virocell stages and considers functional and performance traits of viruses in the context of fitness. Such an integrated view of virus phenotype is necessary for comprehensive interpretation of viral genome sequences and will advance our understanding of viral evolution and ecology.

Indexed as

Genome, ViralPhenotypeGenotypeHumansVirionVirusesVirus Replication

Identifiers

PMID34522049

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.