Evidence map›Paper›PMID 34521964›Full record

ArticleScientific reports2021

Designing multiepitope-based vaccine against Eimeria from immune mapped protein 1 (IMP-1) antigen using immunoinformatic approach.

Thabile Madlala, Victoria T Adeleke, Abiodun J Fatoba, Moses Okpeku, Adebayo A Adeniyi, Matthew A Adeleke

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Frontiers in immunology · 2026
    Article
  3. Article
  4. Article
  5. Immunoinformatics-Aided Design of a Multiepitope Vaccine AgainstBioinformatics and biology insights · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Multi-epitope Based Peptide Vaccine Candidate AgainstBioinformatics and biology insights · 2024
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Thabile MadlalaDiscipline of Genetics, School of Life Sciences, University of KwaZulu-Natal, P/Bag X54001, Westville, Durban, 4000, South Africa.ORCID http://orcid.org/0000-0003-4088-5184
Victoria T AdelekeDiscipline of Chemical Engineering, University of KwaZulu-Natal, Howard Campus, Durban, 4041, South Africa.
Abiodun J FatobaDiscipline of Genetics, School of Life Sciences, University of KwaZulu-Natal, P/Bag X54001, Westville, Durban, 4000, South Africa.
Moses OkpekuDiscipline of Genetics, School of Life Sciences, University of KwaZulu-Natal, P/Bag X54001, Westville, Durban, 4000, South Africa.
Adebayo A AdeniyiDepartment of Chemistry, Faculty of Natural and Agricultural Sciences, University of the Free State, Bloemfontein, South Africa.
Matthew A AdelekeDiscipline of Genetics, School of Life Sciences, University of KwaZulu-Natal, P/Bag X54001, Westville, Durban, 4000, South Africa. adelekem@ukzn.ac.za.ORCID http://orcid.org/0000-0002-3271-8442
University of KwaZulu-Natal · ZAUniversity of the Free State · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug resistance against coccidiosis has posed a significant threat to chicken welfare and productivity worldwide, putting daunting pressure on the poultry industry to reduce the use of chemoprophylactic drugs and live vaccines in poultry to treat intestinal diseases. Chicken coccidiosis, caused by an apicomplexan parasite of Eimeria spp., is a significant challenge worldwide. Due to the experience of economic loss in production and prevention of the disease, development of cost-effective vaccines or drugs that can stimulate defence against multiple Eimeria species is imperative to control coccidiosis. This study explored Eimeria immune mapped protein-1 (IMP-1) to develop a multiepitope-based vaccine against coccidiosis by identifying antigenic T-cell and B-cell epitope candidates through immunoinformatic techniques. This resulted in the design of 7 CD8

Indexed as

AnimalsAntigens, ProtozoanChickensCoccidiosisConserved SequenceEimeriaEpitopes, B-LymphocyteEpitopes, T-LymphocytePoultry DiseasesProtozoan ProteinsProtozoan VaccinesAntigens, ProtozoanEpitopes, B-LymphocyteEpitopes, T-LymphocyteProtozoan ProteinsProtozoan Vaccines

Identifiers

PMID34521964
PMCPMC8440781
OpenAlexW3199626224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.