Observational studyScientific reports2021
Corneal endothelial cell density and morphology in ophthalmologically healthy young individuals in Japan: An observational study of 16842 eyes.
Observational study in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 23 citations in OpenAlex.
- Central corneal endothelial morphometry in emmetropic adults aged 20-40 years examined in Valencia, Spain: a retrospective cross-sectional analysis.Surgical and radiologic anatomy : SRA · 2026Article
- Repeatability and reproducibility of corneal endothelial measurements using the topcon SP-1P specular microscope.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Corneal endothelial morphology in patients with herpetic keratitis attending tertiary eye centre.BMC ophthalmology · 2026Article
- Correlation Between Endothelial Morphology, Ocular Biometric Parameters, and Systemic Comorbidities in a Large Caucasian Cohort.Journal of clinical medicine · 2026Article
- Protocol for culturing healthy primary endothelial cells isolated from research-grade human corneoscleral donor tissue.STAR protocols · 2026Article
- Beyond the Cornea: Systemic Diseases and Their Impact on Endothelial Health-A Narrative Review.Journal of clinical medicine · 2026Review
- Neutrophil-to-Lymphocyte Ratio Is Associated with the Stability of Human Corneal Endothelial Cells.Journal of clinical medicine · 2026Article
- Imaging improvements reveal guttae development and posterior fibrillar layer formation in fuchs endothelial corneal dystrophy.Scientific reports · 2026Article
- Impact of COVID-19 on corneal endothelial density and morphology: a cross-sectional study in convalescent patients.Frontiers in medicine · 2026Article
- Long-term observation of the endothelium morphology and corneal thickness in myopic adolescents treated with orthokeratology: a 10-year retrospective study.International journal of ophthalmology · 2026Article
- Central corneal thickness, corneal endothelial cell density, and morphology in myopic eyes of young Chinese candidates for refractive surgery.Frontiers in ophthalmology · 2026Article
- Exploring corneal endothelial cell dynamics: structure, functions and therapeutic approaches.Molecular biology reports · 2025Review
- Bioengineering Strategies for Corneal Endothelial Cell Injection Therapy: Advances, Challenges, and Clinical Translation.Bioengineering (Basel, Switzerland) · 2025Review
- Comparative Analysis of Descemet Membrane Endothelial Keratoplasty (DMEK) Versus Descemetorhexis Without Keratoplasty (DSO) in Patients with Fuchs Endothelial Corneal Dystrophy.Journal of clinical medicine · 2025Article
- Correlation between early corneal edema and endothelial cell loss after phacoemulsification cataract surgery.Frontiers in medicine · 2025Article
- A Case of Bacterial Keratitis in a Patient Using Orthokeratology and Soft Contact Lenses.Cureus · 2024Article
- Diagnostic Techniques to Increase the Safety of Phakic Intraocular Lenses.Diagnostics (Basel, Switzerland) · 2023Review
- Long-term effect of using hard contact lenses on corneal endothelial cell density and morphology in ophthalmologically healthy individuals in Japan.Scientific reports · 2023Observational
- Corneal densitometry: an innovative method to quantitatively evaluate corneal changes after phacovitrectomy.BMC ophthalmology · 2023Article
- Corneal dystrophy mutations R125H and R804H disable SLC4A11 by altering the extracellular pH dependence of the intracellular pK that governs HAmerican journal of physiology. Cell physiology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We aimed to investigate the cell density and morphology of the corneal endothelium in ophthalmologically healthy young Japanese, given the lack of normative data in literature. This observational study included eyes without ophthalmologic diseases, besides refractive errors, examined between 1996 and 2015 at Miyata Eye Hospital. Eyes with a history of ophthalmologic diseases or contact lens usage were excluded. Correlation of corneal endothelial cell density (ECD), coefficient of variation (CV), appearance rate of hexagonal cells (6A), and cell area with age were examined. Multivariate linear regression analysis was performed to determine the predictors of corneal parameters. We included 16842 eyes of 8421 individuals (19.6 ± 8.7 years). ECD was 3109.0 ± 303.7 cells/mm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.