ArticleNature communications2021
Mechanosensitive recruitment of stator units promotes binding of the response regulator CheY-P to the flagellar motor.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Review
- Rage against the mean: a perspective on measuring fitness of individual phage particles.Npj viruses · 2026Review
- The dynamic response of the bacterial flagellar motor to its direct intracellular input signal.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Evolutionary consequences of bacterial resistance to a flagellotropic phage.bioRxiv : the preprint server for biology · 2025Article
- New Insights into the Mediation of Biofilm Formation by Three Core Extracellular Polysaccharide Biosynthesis Pathways inInternational journal of molecular sciences · 2025Article
- Scrutinizing Stator Rotation in the Bacterial Flagellum: Reconciling Experiments and Switching Models.Biomolecules · 2025Review
- Microscopic phage adsorption assay: High-throughput quantification of virus particle attachment to host bacterial cells.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Structure and Dynamics of the Bacterial Flagellar Motor Complex.Biomolecules · 2024Review
- Structural basis of the bacterial flagellar motor rotational switching.Cell research · 2024Article
- Structural basis of directional switching by the bacterial flagellum.Nature microbiology · 2024Article
- A mobile CRISPRi collection enables genetic interaction studies for the essential genes of Escherichia coli.Cell reports methods · 2024Article
- Structural Basis of Directional Switching by the Bacterial Flagellum.Research square · 2023Article
- Antibacterial Activity and Transcriptomic Analysis of Hesperetin againstFoods (Basel, Switzerland) · 2023Article
- Ion selectivity and rotor coupling of the Vibrio flagellar sodium-driven stator unit.Nature communications · 2023Article
- The FilZ Protein Contains a Single PilZ Domain and Facilitates the Swarming Motility ofMicroorganisms · 2023Article
- Site-Directed Cross-Linking Between Bacterial Flagellar Motor Proteins In Vivo.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Motility provides specific adhesion patterns and improves Listeria monocytogenes invasion into human HEp-2 cells.PloS one · 2023Article
- Measurements of the Ion Channel Activity of the Transmembrane Stator Complex in the Bacterial Flagellar Motor.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Article
- FliL ring enhances the function of periplasmic flagella.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
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Authors and funding
6 authors.
Funding
Abstract
Reversible switching of the bacterial flagellar motor between clockwise (CW) and counterclockwise (CCW) rotation is necessary for chemotaxis, which enables cells to swim towards favorable chemical habitats. Increase in the viscous resistance to the rotation of the motor (mechanical load) inhibits switching. However, cells must maintain homeostasis in switching to navigate within environments of different viscosities. The mechanism by which the cell maintains optimal chemotactic function under varying loads is not understood. Here, we show that the flagellar motor allosterically controls the binding affinity of the chemotaxis response regulator, CheY-P, to the flagellar switch complex by modulating the mechanical forces acting on the rotor. Mechanosensitive CheY-P binding compensates for the load-induced loss of switching by precisely adapting the switch response to a mechanical stimulus. The interplay between mechanical forces and CheY-P binding tunes the chemotactic function to match the load. This adaptive response of the chemotaxis output to mechanical stimuli resembles the proprioceptive feedback in the neuromuscular systems of insects and vertebrates.
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