Evidence map›Paper›PMID 34521685›Full record

ArticleBritish journal of sports medicine2022

Moderate-to-vigorous intensity physical activity from young adulthood to middle age and metabolic disease: a 30-year population-based cohort study.

Jason M Nagata, Eric Vittinghoff, Kelley Pettee Gabriel, Andrea K Garber, Andrew E Moran, Jamal S Rana, Jared P Reis, Stephen Sidney, Kirsten Bibbins-Domingo

Open access · greenAbstract read
In one paragraph

Article in British journal of sports medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 36 citations in OpenAlex.

  1. Gender diversity and cholesterol in early adolescence: Findings from the Adolescent Brain Cognitive Development Study.International journal of cardiology. Cardiovascular risk and prevention · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Jason M NagataDivision of Adolescent and Young Adult Medicine, Department of Pediatrics, University of California San Francisco, San Francisco, California, USA jason.nagata@ucsf.edu.ORCID http://orcid.org/0000-0002-6541-0604
Eric VittinghoffDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA.
Kelley Pettee GabrielDepartment of Epidemiology, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Andrea K GarberDivision of Adolescent and Young Adult Medicine, Department of Pediatrics, University of California San Francisco, San Francisco, California, USA.
Andrew E MoranDivision of General Medicine, Columbia University, New York, New York, USA.
Jamal S RanaDivision of Cardiology, Kaiser Permanente Northern California, Oakland, California, USA.
Jared P ReisDivision of Cardiovascular Sciences, National Heart Lung and Blood Institute, Bethesda, Maryland, USA.
Stephen SidneyDivision of Research, Kaiser Permanente Northern California, Oakland, California, USA.
Kirsten Bibbins-DomingoDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA.
University of California, San Francisco · USKaiser Permanente · USColumbia University · USNational Heart Lung and Blood Institute · USUniversity of Alabama at Birmingham · US

Funding

Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8M
UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6M
Hypertension Management in Minority and Low-income PopulationsK24DK103992 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BIBBINS-DOMINGO, KIRSTEN · 2014 to 2018
$917k
Informing national guidelines on adolescent and young adult physical activity and sedentary behavior to prevent cardiovascular diseaseK08HL159350 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NAGATA, JASON M · 2021 to 2025
$869k
NHLBI NIH HHS HHSN268201800003INHLBI NIH HHS HHSN268201800004INHLBI NIH HHS HHSN268201800005INHLBI NIH HHS HHSN268201800006INHLBI NIH HHS HHSN268201800007INHLBI NIH HHS K08 HL159350NIDDK NIH HHS K24 DK103992NIDDK NIH HHS P30 DK063720NIDDK NIH HHS P30 DK098722
6 · The paper itself

Abstract

objectivesTo determine the association between moderate-to-vigorous intensity physical activity (MVPA) trajectories (course over age and time) through the adult life course and onset of metabolic disease (diabetes and dyslipidaemia).

methodsWe analysed prospective community-based cohort data of 5115 participants in the Coronary Artery Risk Development in Young Adults study, who were black and white men and women aged 18-30 years at baseline (1985-1986) at four urban sites, collected through 30 years of follow-up. Individualised MVPA trajectories were developed for each participant using linear mixed models.

resultsLower estimated MVPA score at age 18 was associated with a 12% (95% CI 6% to 18%) higher odds of incident diabetes, a 4% (95% CI 1% to 7%) higher odds of incident low high-density lipoprotein (HDL) and a 6% (95% CI 2% to 11%) higher odds of incident high triglycerides. Each additional annual 1-unit reduction in the MVPA score was associated with a 6% (95% CI 4% to 9%) higher annual odds of diabetes incidence and a 4% (95% CI 2% to 6%) higher annual odds of high triglyceride incidence. Analysing various MVPA trajectory groups, participants who were in the most active group at age 18 (over 300 min/week), but with sharp declines in midlife, had higher odds of high low-density lipoprotein and low HDL incidence, compared with those in the most active group at age 18 with subsequent gains.

conclusionGiven recent trends in declining MVPA across the life course and associated metabolic disease risk, young adulthood is an important time period for interventions to increase and begin the maintenance of MVPA.

Indexed as

Diabetes MellitusMetabolic DiseasesAdolescentAdultCohort StudiesExerciseFemaleHumansMaleMiddle AgedProspective StudiesRisk FactorsYoung Adultcholesteroldiabetesexercisephysical activity

Identifiers

PMID34521685
PMCPMC9017156
OpenAlexW3200772651

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.