Evidence map›Paper›PMID 34521578›Full record

ArticleJournal of diabetes and its complications2021

Adults with type 2 diabetes benefit from self-management support intervention regardless of depressive symptoms.

Lindsay S Mayberry, Lyndsay A Nelson, Jeffrey S Gonzalez

Open access · greenAbstract read
In one paragraph

Article in Journal of diabetes and its complications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Lindsay S MayberryDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States of America; Vanderbilt Center for Diabetes Translation Research, Nashville, TN, United States of America. Electronic address: lindsay.mayberry@vumc.org.
Lyndsay A NelsonDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States of America; Vanderbilt Center for Diabetes Translation Research, Nashville, TN, United States of America.
Jeffrey S GonzalezFerkauf Graduate School of Psychology, Yeshiva University, Bronx, NY, United States of America; Departments of Medicine (Endocrinology) and Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, United States of America; New York Regional Center for Diabetes Translation Research, Bronx, NY, United States of America.
Vanderbilt University · USVanderbilt University Medical Center · USYeshiva University · US

Funding

Stable Isotope and Metabolomics CoreP60DK020541 · NIDDK · YESHIVA UNIVERSITY · PI PESSIN, JEFFREY E. · 1986 to 2014
$29.8M
Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7M
New York Regional Center for Diabetes Translation Research - Translational Intervention Methodology CoreP30DK111022 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JEFFREY GONZALEZ · 2016 to 2026
$7.8M
Vanderbilt Center for Diabetes Translation ResearchP30DK092986 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ELASY, TOM A · 2011 to 2020
$6.7M
Power-Up Study Administrative Supplement to Promote DiversityR01DK121896 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI CHAMBERS, EARLE C, GONZALEZ, JEFFREY S · 2019 to 2023
$3.6M
Emotional Distress in a Comparative Effectiveness Trial of Diabetes TreatmentsR01DK104845 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI CHERRINGTON, ANDREA L, GONZALEZ, JEFFREY S · 2015 to 2019
$3.4M
Improving Medication Adherence among Underserved Patients with Type 2 DiabetesR01DK100694 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MAYBERRY, LINDSAY S. · 2014 to 2018
$3.3M
Function and Emotion in Everyday Life with Type 1 Diabetes: FEEL-T1DR01DK121298 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GONZALEZ, JEFFREY S, PYATAK, ELIZABETH F · 2019 to 2022
$3.2M
Vanderbilt Scholars in T4 Translational Research (V-STTaR) ProgramK12HL137943 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KRIPALANI, SUNIL, ROUMIE, CHRISTIANNE L. · 2017 to 2021
$2.9M
NHLBI NIH HHS K12 HL137943NIDDK NIH HHS P30 DK020541NIDDK NIH HHS P30 DK092986NIDDK NIH HHS P30 DK111022NIDDK NIH HHS R01 DK100694NIDDK NIH HHS R01 DK104845NIDDK NIH HHS R01 DK121298NIDDK NIH HHS R01 DK121896
6 · The paper itself

Abstract

aimsElevated depressive symptoms are common among adults with type 2 diabetes (T2D). In a secondary analysis from an RCT of a diabetes self-management support intervention that did not target depressive symptoms, we sought to determine if depressive symptoms were reduced by the intervention (i.e., depressive symptoms an outcome) or, alternatively, if intervention effects on hemoglobin A1c were lesser among persons with clinically elevated depressive symptoms (i.e., depressive symptoms an effect modifier).

methodsWe evaluated a text messaging intervention, REACH, in a diverse (half non-white, half underinsured) sample of N = 506 adults with T2D. Participants completed the Patient Health Questionnaire-8 (PHQ) and A1c tests at baseline and 6 months. We conducted a factor analysis to identify somatic- and cognitive-affective symptoms on the PHQ. We tested our hypotheses with regression models, using interaction terms and subgroup analyses.

resultsREACH improved depressive symptoms among participants with lower baseline A1c (<8.5%; β = -0.133, p = .007; cognitive β = -0.107, p = .038; somatic β = -0.131, p = .014) but not among participants with higher baseline A1c (≥8.5%; β = 0.040, p = .468). Baseline depressive symptoms did not modify the effect on A1c.

conclusionsWe found support for the hypothesis that depressive symptoms - both somatic- and cognitive-affective - may be an outcome, rather than an effect modifier, of effective diabetes self-management support interventions.

Indexed as

DepressionDiabetes Mellitus, Type 2Self-ManagementAdultGlycated HemoglobinHumansGlycated HemoglobinDepressive symptomsGlycemic controlRandomized controlled trialType 2 diabetes

Identifiers

PMID34521578
PMCPMC8511161
OpenAlexW3193624906

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.