SynthesisReproductive biology and endocrinology : RB&E2021
Sequential cleavage and blastocyst embryo transfer and IVF outcomes: a systematic review.
Synthesis in Reproductive biology and endocrinology : RB&E, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Sequential embryo transfer efficacy in enhancing pregnancy outcomes: a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2025Pooled it
- The effect of sequential embryo transfer on pregnancy outcomes in patients with recurrent implantation failure: a systematic review and meta-analysis of randomized controlled trials.Archives of gynecology and obstetrics · 2024Pooled it
- Differential Impact of the Endometrial Immune Environment in Fresh Versus Frozen Embryo Transfer.Cells · 2026Trial
- Endometrial immune profiling and precision therapy increase live birth rate after embryo transfer: a randomised controlled trial.Frontiers in immunology · 2025Trial
- Sequential blastocyst transfer improved pregnancy outcomes in patients undergoing frozen-thawed embryo transfer cycles: who will be the ultimate beneficiary.Frontiers in endocrinology · 2026Article
- The Impact of Cleavage and Blastocyst Stage Sequential Transfer on Clinical Pregnancy Outcomes of Frozen Embryo Transfer in Patients with Multiple Transplant Failures: A Retrospective Cohort Study.International journal of women's health · 2026Article
- Sequential Transfer of Blastocysts on Day 5 and Day 6 in Patients with Repeated Implantation Failure in Frozen Embryo Transfer Cycle.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Live birth rate and perinatal outcomes following sequential embryo transfer in women with recurrent implantation failure undergoing frozen-thawed embryo transfer cycles.BMC pregnancy and childbirth · 2025Article
- Comparison of double blastocyst transfer versus sequential transfer on pregnancy outcomes in individuals with frozen embryo transfer and a history of recurrent implantation failure: An RCT.International journal of reproductive biomedicine · 2025Article
- Effects of intrauterine infusion of autologous platelet-rich plasma gel on endometrial thickness and outcomes of frozen-thawed embryo transfer in women with thin endometrium.Journal of assisted reproduction and genetics · 2024Article
- Effect of sequential cleavage and blastocyst embryo transfer compared to single cleavage stage embryo transfer on assisted reproductive technology outcome: An RCT.International journal of reproductive biomedicine · 2024Article
- Predictive models of recurrent implantation failure in patients receiving ART treatment based on clinical features and routine laboratory data.Reproductive biology and endocrinology : RB&E · 2024Review
- Embryo Transfer Strategies for Women with Recurrent Implantation Failure During the Frozen-thawed Embryo Transfer Cycles: Sequential Embryo Transfer or Double-blastocyst Transfer?Current medical science · 2024Article
- Article
- Effect of sequential embryo transfer onFrontiers in medicine · 2023Article
- Sequential embryo transfer versus double cleavage-stage embryo or double blastocyst transfer in patients with recurrent implantation failure with frozen-thawed embryo transfer cycles: a cohort study.Frontiers in endocrinology · 2023Article
- The outcomes of sequential embryo transfer in patients undergoing in vitro fertilization with frozen-thawed embryos: A retrospective study.The journal of obstetrics and gynaecology research · 2022Article
- Recurrent implantation failure: A comprehensive summary from etiology to treatment.Frontiers in endocrinology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundSequential embryo transfer has been proposed as a way to improve embryo implantation in women for in vitro fertilization (IVF), but the effect on pregnancy outcomes remains ambiguous. This systematic review was conducted to investigate the efficacy of sequential embryo transfer on IVF outcomes.
methodsA literature search was performed in the PubMed, Web of Science, Cochrane Library, ScienceDirect and Wanfang databases. Data were pooled using a random- or fixed-effects model according to study heterogeneity. The results are expressed as relative risks (RRs) with 95% confidence intervals (CIs). Heterogeneity was evaluated by the I
resultsTen eligible studies with 2658 participants compared sequential embryo transfer and cleavage transfer, while four studies with 513 participants compared sequential embryo transfer and blastocyst transfer. The synthesis results showed that the clinical pregnancy rate was higher in the sequential embryo transfer group than in the cleavage embryo transfer group (RR 1.42, 95% CI 1.26-1.60, P< 0.01) for both women who did experience repeated implantation failure (RIF) (RR 1.58, 95% CI 1.17-2.13, P< 0.01) and did not experience RIF (Non-RIF) (RR 1.44, 95% CI 1.20-1.66, P< 0.01). However, sequential embryo transfer showed no significant benefit over blastocyst embryo transfer.
conclusionThe current systematic review demonstrates that sequential cleavage and blastocyst embryo transfer improve the clinical pregnancy rate over conventional cleavage embryo transfer. For women with adequate embryos, sequential transfer could be attempted following careful consideration. More high-grade evidence from prospective randomized studies is warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.