ArticleBMC neurology2021
Diazepam induced sleep spindle increase correlates with cognitive recovery in a child with epileptic encephalopathy.
Article in BMC neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Closed-loop modulation of sleep in children undergoing intracranial recordings.Cell reports. Medicine · 2026Trial
- Spike-spindle coupling during sleep and its mechanism explanation in childhood focal epilepsy.Cognitive neurodynamics · 2024Article
- Impaired sleep-dependent memory consolidation predicted by reduced sleep spindles in Rolandic epilepsy.bioRxiv : the preprint server for biology · 2024Article
- Preliminary evidence of a relationship between sleep spindles and treatment response in epileptic encephalopathy.Annals of clinical and translational neurology · 2023Article
- Preliminary evidence of a relationship between sleep spindles and treatment response in epileptic encephalopathy.bioRxiv : the preprint server for biology · 2023Article
- Article
- Assessment of Cognitive Function with Sleep Spindle Characteristics in Adults with Epilepsy.Neural plasticity · 2023Article
- Electrophysiological markers of memory consolidation in the human brain when memories are reactivated during sleep.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Source EEG reveals that Rolandic epilepsy is a regional epileptic encephalopathy.NeuroImage. Clinical · 2022Article
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundContinuous spike and wave of sleep with encephalopathy (CSWS) is a rare and severe developmental electroclinical epileptic encephalopathy characterized by seizures, abundant sleep activated interictal epileptiform discharges, and cognitive regression or deceleration of expected cognitive growth. The cause of the cognitive symptoms is unknown, and efforts to link epileptiform activity to cognitive function have been unrevealing. Converging lines of evidence implicate thalamocortical circuits in these disorders. Sleep spindles are generated and propagated by the same thalamocortical circuits that can generate spikes and, in healthy sleep, support memory consolidation. As such, sleep spindle deficits may provide a physiologically relevant mechanistic biomarker for cognitive dysfunction in epileptic encephalopathies. CASE PRESENTATION: We describe the longitudinal course of a child with CSWS with initial cognitive regression followed by dramatic cognitive improvement after treatment. Using validated automated detection algorithms, we analyzed electroencephalograms for epileptiform discharges and sleep spindles alongside contemporaneous neuropsychological evaluations over the course of the patient's disease. We found that sleep spindles increased dramatically with high-dose diazepam treatment, corresponding with marked improvements in cognitive performance. We also found that the sleep spindle rate was anticorrelated to spike rate, consistent with a competitively shared underlying thalamocortical circuitry.
conclusionsEpileptic encephalopathies are challenging electroclinical syndromes characterized by combined seizures and a deceleration or regression in cognitive skills over childhood. This report identifies thalamocortical circuit dysfunction in a case of epileptic encephalopathy and motivates future investigations of sleep spindles as a biomarker of cognitive function and a potential therapeutic target in this challenging disease.
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