Evidence map›Paper›PMID 34521256›Full record

ReviewAdvances in wound care2022

Current Understanding of Pathological Mechanisms of Lymphedema.

Cynthia Sung, Sarah Wang, Jerry Hsu, Roy Yu, Alex K Wong

Registry-linked trialAbstract readReview
In one paragraph

Review in Advances in wound care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07498868 (Detecting the Undetected), which is not on this map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07498868 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Detecting the Undetected: an Observational Cohort Study Evaluating the Health Economics, Clinical Utility, and Patient and Staff Experiences of Innovative Peptide Testing to Screen for Heart Failure in Lymphoedema Clinics

TypeobservationalSponsorSwansea Bay University Health BoardRan2026 to 2028Enrolled618ConditionsLymphedema, Lower Limb, Lymphedema, Heart Failure, Heart Failure (for Example, Fluid Overload)
3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Lymphatic transport in anti-tumor immunity and metastasis.The Journal of experimental medicine · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. AInternational journal of molecular sciences · 2024
    Article
  19. Molecular pathophysiology of secondary lymphedema.Frontiers in cell and developmental biology · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Cynthia SungKeck School of Medicine of USC, Los Angeles, California, USA.ORCID 0000-0003-2805-0475
Sarah WangDivision of Plastic and Reconstructive Surgery, Keck School of Medicine of USC, Los Angeles, California, USA.ORCID 0000-0002-7956-2393
Jerry HsuDivision of Plastic Surgery, City of Hope National Medical Center, Duarte, California, USA.ORCID 0000-0002-9870-3286
Roy YuKeck School of Medicine of USC, Los Angeles, California, USA.ORCID 0000-0001-9787-5388
Alex K WongDivision of Plastic Surgery, City of Hope National Medical Center, Duarte, California, USA.ORCID 0000-0002-4068-5230

Funding

Mentored Career DevelopmentKL2TR001854 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Elizabeth Rhea Erwin Burner, Amy Elizabeth West · 2016 to 2026
$9.0M
Retinoic Acid Induced Lymphangiogenesis for Post-Surgical LymphedemaR01HL157626 · NHLBI · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI WONG, ALEX K. · 2021 to 2025
$3.2M
Investigation of 9-cis Retinoic Acid as a Novel Treatment for Post-Surgical LymphedemaK08HL132110 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI WONG, ALEX K. · 2017 to 2020
$712k
NCATS NIH HHS KL2 TR001854NHLBI NIH HHS K08 HL132110NHLBI NIH HHS R01 HL157626
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Lymphatic VesselsLymphedemaFibrosisHumansInflammationLymphatic Systemadipose depositionfibrosisinflammationlymphedemapathophysiology

Identifiers

PMID34521256
PMCPMC9051876

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.