Evidence map›Paper›PMID 34520792›Full record

ArticleToxicology and applied pharmacology2021

Down-regulation of lncRNA MEG3 promotes chronic low dose cadmium exposure-induced cell transformation and cancer stem cell-like property.

Hsuan-Pei Lin, Matthew Rea, Zhishan Wang, Chengfeng Yang

Open access · greenAbstract read
In one paragraph

Article in Toxicology and applied pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Epigenetic downregulation of OEnvironmental pollution (Barking, Essex : 1987) · 2024
    Article
  7. Review
  8. Up-regulation of RNA mToxicology and applied pharmacology · 2023
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Hsuan-Pei LinDepartment of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY 40506, United States of America.
Matthew ReaDepartment of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40536, United States of America.
Zhishan WangDivision of Cancer Biology, Department of Medicine, MetroHealth Medical Center, Case Western University School of Medicine, Cleveland, OH 44109, United States of America.
Chengfeng YangDivision of Cancer Biology, Department of Medicine, MetroHealth Medical Center, Case Western University School of Medicine, Cleveland, OH 44109, United States of America. Electronic address: Chengfeng.yang@case.edu.
University of Kentucky · USMetroHealth Medical Center · USWestern University of Health Sciences · US

Funding

Dysregulations of functional RNA modifications and hexavalent chromium lungcarcinogenesisR01ES032787 · NIEHS · STATE UNIVERSITY NEW YORK STONY BROOK · PI Chengfeng Yang · 2022 to 2026
$2.1M
MECHANISM OF HEXAVALENT CHROMIUM CARCINOGENESIS ROLE OF LONG NON-CODING RNA DYSREGULATIONR01ES029942 · NIEHS · UNIVERSITY OF KENTUCKY · PI YANG, CHENGFENG · 2019 to 2023
$1.8M
THE EPIGENETIC MECHANISM OF HEXAVALENT CHROMIUM CARCINOGENESISR01ES026151 · NIEHS · UNIVERSITY OF KENTUCKY · PI YANG, CHENGFENG · 2016 to 2020
$1.7M
MGMT DOWN-REGULATION IN THE CARCINOGENICITY OF HEXAVALENT CHROMIUMR01ES029496 · NIEHS · UNIVERSITY OF KENTUCKY · PI WANG, ZHISHAN · 2019 to 2023
$1.7M
NIEHS NIH HHS R01 ES026151NIEHS NIH HHS R01 ES029496NIEHS NIH HHS R01 ES029942NIEHS NIH HHS R01 ES032787
6 · The paper itself

Abstract

Cadmium (Cd) is a toxic heavy metal and one of carcinogens that cause lung cancer. However, the exact mechanism of Cd carcinogenesis remains unclear. To investigate the mechanism of Cd carcinogenesis, we exposed human bronchial epithelial cells (BEAS-2B) to a low dose of Cd (2.5 μM, CdCl

Indexed as

ApoptosisApoptosis Regulatory ProteinsBronchiCadmium ChlorideCell Cycle ProteinsCell LineCell ProliferationCell Transformation, NeoplasticDNA MethylationDNA Modification MethylasesEpigenesis, GeneticEpithelial CellsGene Expression Regulation, NeoplasticHumansLung NeoplasmsNeoplastic Stem CellsApoptosis Regulatory ProteinsCadmium ChlorideCell Cycle ProteinsDNA Modification MethylasesMEG3 non-coding RNA, humanRNA, Long NoncodingCadmiumCarcinogenesisEpigeneticsLong Non-coding RNAMEG3

Identifiers

PMID34520792
PMCPMC8511074
OpenAlexW3201068910

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.