Evidence map›Paper›PMID 34520711›Full record

ArticleCurrent biology : CB2021

Membrane trafficking: Retrofusion as an escape route out of the endosome.

Emily R Eden, Clare E Futter

Abstract readComment
PubMed Publisher
In one paragraph

Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. AnalysisbioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Revisiting the role of Annexins in membrane trafficking.Cellular and molecular life sciences : CMLS · 2025
    Review
  6. Intracellular Cholesterol Trafficking.Cold Spring Harbor perspectives in biology · 2023
    Review
  7. Article
  8. Annexins Bridging the Gap: Novel Roles in Membrane Contact Site Formation.Frontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Emily R EdenUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK. Electronic address: e.eden@ucl.ac.uk.
Clare E FutterUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK. Electronic address: c.futter@ucl.ac.uk.

Funding

Medical Research Council MR/V013882/1
6 · The paper itself

Abstract

Intraluminal vesicles accumulate within the endosomal lumen before lysosomal delivery or extracellular release. A new study reports the development of an elegant assay showing that these vesicles can escape from the endosomal lumen by 'back-fusion' or 'retrofusion' with the endosomal limiting membrane.

Indexed as

EndosomesIntracellular MembranesLysosomes

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.