Chemoenzymatic Asymmetric Synthesis of Pyridine-Based α-Fluorinated Secondary Alcohols.

Timo Broese, Peter Ehlers, Peter Langer, Jan von Langermann

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In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.2field-weighted citation impact, top 47% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

Chemoenzymatic Asymmetric Synthesis of Pyridine-Based α-Fluorinated Secondary Alcohols.Chembiochem : a European journal of chemical biology · 2021
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Timo BroeseInstitute of Chemistry, Biocatalytic Synthesis Group, University of Rostock, Albert-Einstein-Str. 3 A, 18059, Rostock, Germany.

Peter EhlersInstitute of Chemistry, Organic Chemistry, University of Rostock, Albert-Einstein-Str. 3 A, 18059, Rostock, Germany.

Peter LangerInstitute of Chemistry, Organic Chemistry, University of Rostock, Albert-Einstein-Str. 3 A, 18059, Rostock, Germany.

Jan von LangermannInstitute of Chemistry, Biocatalytic Synthesis Group, University of Rostock, Albert-Einstein-Str. 3 A, 18059, Rostock, Germany.ORCID 0000-0001-9302-9803

University of Rostock · DE

Funding

Central SME Innovation Programme 16KN073233Central SME Innovation Programme ZF4402103CR9Federal Ministry for Economic Affairs and Energy and "Response" FKZ03ZZ0903I

6 · The paper itself

Abstract

Fluoro-substituted and heteroaromatic compounds are valuable intermediates for a variety of applications in pharma- and agrochemistry and synthetic chemistry. This study investigates the chemoenzymatic preparation of chiral alcohols bearing a heteroaromatic ring with an increasing degree of fluorination in α-position. Starting from readily available picoline derivatives prochiral α-halogenated acyl moieties were introduced with excellent selectivity and 64-95 % yield. The formed carbonyl group was subsequently reduced to the corresponding alcohols using the alcohol dehydrogenase from Lactobacillus kefir, yielding an enantiomeric excess of 95->99 % and up to 98 % yield.

Indexed as

Alcohol DehydrogenaseAlcoholsHalogenationLactobacillusMolecular StructurePyridinesAlcohol DehydrogenaseAlcoholsPyridinesalcoholenantioselectivityenzymesfluorineheteroaromatic

Identifiers

PMID34520599

DOI10.1002/cbic.202100392

PMCPMC9293303

OpenAlexW3200654263

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.