Evidence map›Paper›PMID 34520574›Full record

ArticleMedical physics2021

An endovaginal MRI array with a forward-looking coil for advanced gynecological cancer brachytherapy procedures: Design and initial results.

Akbar Alipour, Akila N Viswanathan, Ronald D Watkins, Hassan Elahi, Wolfgang Loew, Eric Meyer, Marc Morcos, Henry R Halperin, Ehud J Schmidt

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Akbar AlipourDepartment of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Akila N ViswanathanDepartment of Radiation Oncology & Molecular Radiation Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
Ronald D WatkinsDepartment of Radiology, Stanford University, Stanford, California, USA.
Hassan ElahiDepartment of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Wolfgang LoewDepartment of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Eric MeyerDepartment of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Marc MorcosDepartment of Radiation Oncology & Molecular Radiation Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
Henry R HalperinDepartment of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Ehud J SchmidtDepartment of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Johns Hopkins Medicine · USJohns Hopkins University · USCincinnati Children's Hospital Medical Center · USIcahn School of Medicine at Mount Sinai · USStanford University · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Improved Targeting and Assessment of Electrophysiology InterventionR01HL094610 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HALPERIN, HENRY R · 2009 to 2018
$15.5M
Multiparametric Magnetic Resonance Imaging as a Novel Approach to Brachytherapy for Cervical CancerR01CA237005 · NCI · JOHNS HOPKINS UNIVERSITY · PI VISWANATHAN, AKILA · 2020 to 2024
$2.8M
NCI NIH HHS R01 CA237005NHLBI NIH HHS R01 HL094610NIH HHS R01CA237005NIH HHS R01HL094610
6 · The paper itself

Abstract

purposeTo develop an endovaginal MRI array that provides signal enhancement forward into the posterior parametrium and sideways into the vaginal wall, accelerating multiple-contrast detection of residual tumors that survive external beam radiation. The array's enclosure should form an obturator for cervical cancer brachytherapy, allowing integration with MRI-guided catheter placement, CT, and interstitial radiation dose delivery.

methodsThe endovaginal array consisted of forward-looking and sideways-looking components. The forward-looking element imaged the cervix and posterior endometrium, and the sideways-looking elements imaged the vaginal wall. Electromagnetic simulation was performed to optimize the geometry of a forward-looking coil placed on a conductive-metallic substrate, extending the forward penetration above the coil's tip. Thereafter, an endovaginal array with one forward-looking coil and four sideways-looking elements was constructed and tested at 1.5 Tesla in saline and gel phantoms, and three sexually mature swine. Each coil's tuning, matching, and decoupling were optimized theoretically, implemented with electronic circuits, and validated with network-analyzer measurements. The array enclosure emulates a conventional brachytherapy obturator, allowing use of the internal imaging array together with tandem coils and interstitial catheters, as well as use of the enclosure alone during CT and radiation delivery. To evaluate the receive magnetic field (

resultsSimulated

conclusionsHigher SNR gynecological imaging is supported by forward-looking and sideways-looking coils. A forward-looking endovaginal coil for cervix and parametrium imaging was built with optimized metal backing. Array placement within an obturator enhanced integration with the brachytherapy procedure and accelerated imaging for detecting postexternal-beam residual tumors.

Indexed as

BrachytherapyUterine Cervical NeoplasmsAnimalsEquipment DesignFemaleHumansMagnetic Resonance ImagingPhantoms, ImagingSignal-To-Noise RatioSwinecervical cancer imagingforward-looking coilinterventional MRI coils

Identifiers

PMID34520574
PMCPMC8817785
OpenAlexW3199340389

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.