Evidence map›Paper›PMID 34520018›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

A Mesoscale 3D Culture System for Native and Engineered Biphasic Tissues: Application to the Osteochondral Unit.

Irene Chiesa, Roberto Di Gesù, Kalon J Overholt, Riccardo Gottardi

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Irene ChiesaResearch Center 'E. Piaggio', University of Pisa, Pisa, Italy.
Roberto Di GesùDepartment of Pediatrics, Division of Pulmonary Medicine, The Children's Hospital of Philadelphia and The University of Pennsylvania, Philadelphia, PA, USA.
Kalon J OverholtCenter for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Riccardo GottardiDepartment of Pediatrics, Division of Pulmonary Medicine, The Children's Hospital of Philadelphia and The University of Pennsylvania, Philadelphia, PA, USA. gottardir@email.chop.edu.
Children's Hospital of Philadelphia · USRi.MED · ITWhitehead Institute for Biomedical Research · US

Funding

3-D Osteochondral Micro-tissue to Model Pathogenesis of OsteoarthritisU18TR000532 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TUAN, ROCKY S · 2012 to 2013
$788k
NCATS NIH HHS U18 TR000532
6 · The paper itself

Abstract

Interface tissues are functionally graded tissues characterized by a complex layered structure, which therefore present a great challenge to be reproduced and cultured in vitro. Here, we describe the design and operation of a 3D printed dual-chamber bioreactor as a culturing system for biphasic native or engineered osteochondral tissues. The bioreactor is designed to potentially accommodate a variety of interface tissues and enables the precise study of tissue crosstalk by creating two separate microenvironments while maintaining the tissue compartments in direct contact.

Indexed as

Tissue EngineeringBioreactorsCartilageTissue ScaffoldsBioreactorBiphasic constructsCrosstalkInterface tissue engineeringMicrophysiological systemOsteochondral junctionParacrine signaling

Identifiers

PMID34520018
OpenAlexW3199880727

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.