Evidence map›Paper›PMID 34519927›Full record

ArticleIrish journal of medical science2022

Can we trust in Sars-CoV-2 rapid antigen testing? Preliminary results from a paediatric cohort in the emergency department.

Marco Denina, Virginia Giannone, Antonio Curtoni, Elisa Zanotto, Silvia Garazzino, Antonio Francesco Urbino, Claudia Bondone

Open access · bronzeAbstract read
In one paragraph

Article in Irish journal of medical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 4 pooled it
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 4 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Rapid, point-of-care antigen tests for diagnosis of SARS-CoV-2 infection.The Cochrane database of systematic reviews · 2025
    Pooled it
  2. Pooled it
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  5. Observational
  6. Article
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Marco DeninaDepartment of Pediatric Emergency, Regina Margherita Children's Hospital, Turin, Italy. marco.denina@gmail.com.ORCID http://orcid.org/0000-0002-8495-1844
Virginia GiannoneDepartment of Pediatrics and Public Health, University of Turin, Regina Margherita Children's Hospital, Turin, Italy.
Antonio CurtoniDepartment of Public Health and Pediatrics, Microbiology and Virology Unit, Molinette Hospital, University of Turin, Città della salute e della Scienza, Turin, Italy.
Elisa ZanottoDepartment of Public Health and Pediatrics, Microbiology and Virology Unit, Molinette Hospital, University of Turin, Città della salute e della Scienza, Turin, Italy.
Silvia GarazzinoDepartment of Pediatrics, Infectious Diseases Unit, University of Turin, Regina Margherita Children's Hospital, Turin, Italy.
Antonio Francesco UrbinoDepartment of Pediatric Emergency, Regina Margherita Children's Hospital, Turin, Italy.
Claudia BondoneDepartment of Pediatric Emergency, Regina Margherita Children's Hospital, Turin, Italy.
Ospedale Regina Margherita · ITFondazione Ricerca Molinette · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRapid identification of Covid-19 in the paediatric emergency department is critical; Antigen tests are fast but poorly investigated in children.

aimsTo investigate Sars-CoV-2 antigen rapid test in children.

methodsWe compare the performance of LumiraDx with molecular tests in a paediatric emergency department.

resultsA retrospective cohort of 191 patients with AT and PCR tests performed in the same episode was analysed; 16% resulted positive for Sars-CoV-2. Using the PCR test as the gold standard, we calculated antigen testing overall sensitivity of 94.1%, specificity of 91.9%, and NPV of 99.4%. Only one false-negative test was found.

conclusionsAT may be helpful in the initial screening of patients at PED.

Indexed as

COVID-19SARS-CoV-2ChildEmergency Service, HospitalHumansRetrospective StudiesSensitivity and SpecificityAntigen testsCOVID-19Emergency departmentPoint-of-care testsSars-Cov-2

Identifiers

PMID34519927
PMCPMC8438652
OpenAlexW3201566479

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.