Evidence map›Paper›PMID 34519572›Full record

ArticleRadiology2021

Fully Automated Volumetric Breast Density Estimation from Digital Breast Tomosynthesis.

Aimilia Gastounioti, Lauren Pantalone, Christopher G Scott, Eric A Cohen, Fang F Wu, Stacey J Winham, Matthew R Jensen, Andrew D A Maidment, Celine M Vachon, Emily F Conant and 1 more

Open access · greenAbstract read
In one paragraph

Article in Radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
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  7. Observational
  8. Review
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  20. Breast Density Analysis Using Digital Breast Tomosynthesis.bioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Aimilia GastouniotiFrom the Department of Radiology, University of Pennsylvania, 3700 Hamilton Walk, Richards Bldg, Room D702, Philadelphia, PA 19104 (A.G., L.P., E.A.C., A.D.A.M., E.F.C., D.K.); and the Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minn (C.G.S., F.F.W., S.J.W., M.R.J., C.M.V.).ORCID 0000-0002-3359-7195
Lauren PantaloneFrom the Department of Radiology, University of Pennsylvania, 3700 Hamilton Walk, Richards Bldg, Room D702, Philadelphia, PA 19104 (A.G., L.P., E.A.C., A.D.A.M., E.F.C., D.K.); and the Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minn (C.G.S., F.F.W., S.J.W., M.R.J., C.M.V.).
Christopher G ScottFrom the Department of Radiology, University of Pennsylvania, 3700 Hamilton Walk, Richards Bldg, Room D702, Philadelphia, PA 19104 (A.G., L.P., E.A.C., A.D.A.M., E.F.C., D.K.); and the Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minn (C.G.S., F.F.W., S.J.W., M.R.J., C.M.V.).ORCID 0000-0003-1340-0647
Eric A CohenFrom the Department of Radiology, University of Pennsylvania, 3700 Hamilton Walk, Richards Bldg, Room D702, Philadelphia, PA 19104 (A.G., L.P., E.A.C., A.D.A.M., E.F.C., D.K.); and the Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minn (C.G.S., F.F.W., S.J.W., M.R.J., C.M.V.).ORCID 0000-0002-5067-8835
Fang F WuFrom the Department of Radiology, University of Pennsylvania, 3700 Hamilton Walk, Richards Bldg, Room D702, Philadelphia, PA 19104 (A.G., L.P., E.A.C., A.D.A.M., E.F.C., D.K.); and the Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minn (C.G.S., F.F.W., S.J.W., M.R.J., C.M.V.).
Stacey J WinhamFrom the Department of Radiology, University of Pennsylvania, 3700 Hamilton Walk, Richards Bldg, Room D702, Philadelphia, PA 19104 (A.G., L.P., E.A.C., A.D.A.M., E.F.C., D.K.); and the Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minn (C.G.S., F.F.W., S.J.W., M.R.J., C.M.V.).ORCID 0000-0002-8492-9102
Matthew R JensenFrom the Department of Radiology, University of Pennsylvania, 3700 Hamilton Walk, Richards Bldg, Room D702, Philadelphia, PA 19104 (A.G., L.P., E.A.C., A.D.A.M., E.F.C., D.K.); and the Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minn (C.G.S., F.F.W., S.J.W., M.R.J., C.M.V.).
Andrew D A MaidmentFrom the Department of Radiology, University of Pennsylvania, 3700 Hamilton Walk, Richards Bldg, Room D702, Philadelphia, PA 19104 (A.G., L.P., E.A.C., A.D.A.M., E.F.C., D.K.); and the Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minn (C.G.S., F.F.W., S.J.W., M.R.J., C.M.V.).ORCID 0000-0003-1074-7063
Celine M VachonFrom the Department of Radiology, University of Pennsylvania, 3700 Hamilton Walk, Richards Bldg, Room D702, Philadelphia, PA 19104 (A.G., L.P., E.A.C., A.D.A.M., E.F.C., D.K.); and the Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minn (C.G.S., F.F.W., S.J.W., M.R.J., C.M.V.).ORCID 0000-0002-1962-9322
Emily F ConantFrom the Department of Radiology, University of Pennsylvania, 3700 Hamilton Walk, Richards Bldg, Room D702, Philadelphia, PA 19104 (A.G., L.P., E.A.C., A.D.A.M., E.F.C., D.K.); and the Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minn (C.G.S., F.F.W., S.J.W., M.R.J., C.M.V.).ORCID 0000-0001-9331-644X
Despina KontosFrom the Department of Radiology, University of Pennsylvania, 3700 Hamilton Walk, Richards Bldg, Room D702, Philadelphia, PA 19104 (A.G., L.P., E.A.C., A.D.A.M., E.F.C., D.K.); and the Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minn (C.G.S., F.F.W., S.J.W., M.R.J., C.M.V.).ORCID 0000-0001-9031-5126
Mayo Clinic · US

Funding

Effect of Breast Density on Screening Recall with Digital Breast TomosynthesisR01CA161749 · NCI · UNIVERSITY OF PENNSYLVANIA · PI KONTOS, DESPINA · 2012 to 2021
$3.6M
Radiomic phenotypes of breast parenchyma and association with breast cancer risk and detectionR01CA207084 · NCI · MAYO CLINIC ROCHESTER · PI KERLIKOWSKE, KARLA M, KONTOS, DESPINA · 2017 to 2021
$3.2M
Cancer imaging phenomics software suite: application to brain and breast cancerU24CA189523 · NCI · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS, KONTOS, DESPINA · 2015 to 2019
$3.2M
Automated Density Measures for Estimating Breast Cancer Risk and Therapy ResponseR01CA177150 · NCI · MAYO CLINIC ROCHESTER · PI KERLIKOWSKE, KARLA M, VACHON, CELINE M · 2013 to 2017
$3.0M
Biomedical Image Computing and Informatics ClusterS10OD023495 · OD · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS · 2017 to 2017
$1.9M
NCI NIH HHS R01 CA161749NCI NIH HHS R01 CA177150NCI NIH HHS R01 CA207084NCI NIH HHS U24 CA189523NIH HHS S10 OD023495
6 · The paper itself

Abstract

Background While digital breast tomosynthesis (DBT) is rapidly replacing digital mammography (DM) in breast cancer screening, the potential of DBT density measures for breast cancer risk assessment remains largely unexplored. Purpose To compare associations of breast density estimates from DBT and DM with breast cancer. Materials and Methods This retrospective case-control study used contralateral DM/DBT studies from women with unilateral breast cancer and age- and ethnicity-matched controls (September 19, 2011-January 6, 2015). Volumetric percent density (VPD%) was estimated from DBT using previously validated software. For comparison, the publicly available Laboratory for Individualized Breast Radiodensity Assessment software package, or LIBRA, was used to estimate area-based percent density (APD%) from raw and processed DM images. The commercial Quantra and Volpara software packages were applied to raw DM images to estimate VPD% with use of physics-based models. Density measures were compared by using Spearman correlation coefficients (

Indexed as

Breast DensityBreastBreast NeoplasmsCase-Control StudiesFemaleHumansMammographyMiddle AgedRetrospective Studies

Identifiers

PMID34519572
PMCPMC8608738
OpenAlexW3201070283

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.