Evidence map›Paper›PMID 34519520›Full record

ArticlemSystems2021

Higher Trimethylamine-

Silke Rath, Katharina Rox, Sven Kleine Bardenhorst, Ulf Schminke, Marcus Dörr, Julia Mayerle, Fabian Frost, Markus M Lerch, André Karch, Mark Brönstrup and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSystems, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Trimethylamine-Annals of medicine · 2025
    Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Silke Rath *Microbial Interactions and Processes Research Group, Helmholtz Centre for Infection Researchgrid.7490.a, Braunschweig, Germany.
Katharina Rox *Department of Chemical Biology, Helmholtz Centre for Infection Researchgrid.7490.a, Braunschweig, Germany.
Sven Kleine Bardenhorst *Institute of Epidemiology and Social Medicine, University of Münstergrid.5949.1, Münster, Germany.
Ulf SchminkeDepartment of Neurology, University Medicine Greifswald, Greifswald, Germany.
Marcus DörrDepartment of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
Julia MayerleDepartment of Medicine II, University Hospital Munich, Ludwig-Maximillian University Munich, Munich, Germany.
Fabian FrostDepartment of Medicine A, University Medicine Greifswald, Greifswald, Germany.
Markus M LerchDepartment of Medicine A, University Medicine Greifswald, Greifswald, Germany.
André KarchInstitute of Epidemiology and Social Medicine, University of Münstergrid.5949.1, Münster, Germany.
Mark BrönstrupDepartment of Chemical Biology, Helmholtz Centre for Infection Researchgrid.7490.a, Braunschweig, Germany.ORCID 0000-0002-8971-7045
Dietmar H PieperMicrobial Interactions and Processes Research Group, Helmholtz Centre for Infection Researchgrid.7490.a, Braunschweig, Germany.
Marius VitalMicrobial Interactions and Processes Research Group, Helmholtz Centre for Infection Researchgrid.7490.a, Braunschweig, Germany.ORCID 0000-0003-4185-3475
Universitätsmedizin Greifswald · DEHelmholtz Centre for Infection Research · DEUniversity of Münster · DEGerman Center for Infection Research · DELudwig-Maximilians-Universität München · DEMedizinische Hochschule Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbiota-dependent metabolite trimethylamine-

Indexed as

agingcardiovascular diseasedietmicrobiotatrimethylamine

Identifiers

PMID34519520
PMCPMC8547441
OpenAlexW3199610774

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.