Evidence map›Paper›PMID 34519376›Full record

ReviewChemistry (Weinheim an der Bergstrasse, Germany)2021

Synthesis and Transformations of NH-Sulfoximines.

Michael Andresini, Arianna Tota, Leonardo Degennaro, James A Bull, Renzo Luisi

Abstract readReview
In one paragraph

Review in Chemistry (Weinheim an der Bergstrasse, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Review
  2. Article
  3. RapidThe Journal of organic chemistry · 2026
    Article
  4. Article
  5. RSC medicinal chemistry · 2026
    Article
  6. Article
  7. Article
  8. SulfoximineThe Journal of organic chemistry · 2025
    Article
  9. A General Metallaphotoredox Platform forJournal of the American Chemical Society · 2025
    Article
  10. π-Electron Donation at the Sulfoximidoyl Nitrogen Atom.Angewandte Chemie (International ed. in English) · 2025
    Article
  11. Article
  12. B(CChemistry (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michael AndresiniDepartment of Pharmacy-Drug Sciences, University of Bari "A. Moro", Via E. Orabona 4, 70125, Bari, Italy.
Arianna TotaDepartment of Pharmacy-Drug Sciences, University of Bari "A. Moro", Via E. Orabona 4, 70125, Bari, Italy.
Leonardo DegennaroDepartment of Pharmacy-Drug Sciences, University of Bari "A. Moro", Via E. Orabona 4, 70125, Bari, Italy.
James A BullDepartment of Chemistry Imperial College London, Molecular Sciences Research Hub White City Campus, Wood Lane, London, W12 0BZ, UK.ORCID http://orcid.org/0000-0003-3993-5818
Renzo LuisiDepartment of Pharmacy-Drug Sciences, University of Bari "A. Moro", Via E. Orabona 4, 70125, Bari, Italy.ORCID http://orcid.org/0000-0002-9882-7908

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent years have seen a marked increase in the occurrence of sulfoximines in the chemical sciences, often presented as valuable motifs for medicinal chemistry. This has been prompted by both pioneering works taking sulfoximine containing compounds into clinical trials and the concurrent development of powerful synthetic methods. This review covers recent developments in the synthesis of sulfoximines concentrating on developments since 2015. This includes extensive developments in both S-N and S-C bond formations. Flow chemistry processes for sulfoximine synthesis are also covered. Finally, subsequent transformations of sulfoximines, particularly in N-functionalization are reviewed, including N-S, N-P, N-C bond forming processes and cyclization reactions.

Indexed as

Chemistry, PharmaceuticalCyclizationMolecular Structurehypervalent iodinenitrogen transferorganic synthesisorganosulfursulfoximines

Identifiers

PMID34519376
PMCPMC9291533

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.