Trial reportAmerican journal of hypertension2022
Long-Term Blood Pressure Variability and Kidney Function in Participants of the ASPREE Trial.
Trial report in American journal of hypertension, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01038583 (Aspirin in Reducing Events in the Elderly), which is not on this map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Aspirin in Reducing Events in the Elderly
Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Clonal Hematopoiesis and Kidney Function in the ASPREE Cohort.Kidney international reports · 2026Article
- Research progress on the correlation between blood pressure variability and hypertensive microvascular disease.Frontiers in cardiovascular medicine · 2026Review
- Late-life, visit-to-visit blood pressure variability and its association with sex-specific long-term cognitive outcomes.Journal of human hypertension · 2025Article
- Association of Blood Pressure Variability with Contrast Nephropathy in STEMI Patients Undergoing Primary PCI.Acta Cardiologica Sinica · 2025Article
- Association Between Blood Pressure Variation During Dialysis and Cardio-Cerebrovascular Events.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Effects of long-term blood pressure variability on renal function in community population.Chronic diseases and translational medicine · 2024Article
- Association of blood pressure variability with target organ damage in older patients with essential hypertension.Chronic diseases and translational medicine · 2023Article
- GFR Variability, Survival, and Cardiovascular Events in Older Adults.Kidney medicine · 2023Article
- Accelerated Peripapillary Retinal Nerve Fiber Layer Degeneration in Patients With Chronic Kidney Disease: A 2-Year Longitudinal Study.Translational vision science & technology · 2022Article
- The Sequential Change in Left Ventricular Function among Various Cardiovascular Diseases: A 12-Year Study.Journal of personalized medicine · 2022Article
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Authors and funding
12 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundWhether long-term blood pressure variability (BPV) predicts kidney function decline in generally healthy older adults is unknown. We investigated this association in ASPirin in Reducing Events in the Elderly (ASPREE) trial participants.
methodsBetween 2010 and 2014, Australian and US individuals aged ≥70 years (≥65 if US minority) were recruited and followed with annual study visits for a median of 4.7 years. Time-to-event analyses and linear mixed effects models were used to examine associations between incident chronic kidney disease (CKD), and trajectories of estimated glomerular filtration rate (eGFR) and log albumin-creatinine ratio (log ACR) with systolic BPV as a continuous measure, and, by tertile of SD of systolic blood pressure (BP). BPV was estimated using systolic BP measures from baseline through the second annual visit, and kidney outcomes were assessed following this period.
resultsIncident CKD occurred in 1,829 of 6,759 participants (27.2%), and more commonly in BPV tertiles 2 (27.4%) and 3 (28.3%) than tertile 1 (25.5%); however, the risk was not significantly increased after covariate adjustment (tertile 3 hazard ratio = 1.02; 95% confidence interval: 0.91-1.14). Analysis of eGFR (n = 16,193) and log ACR trajectories (n = 15,213) showed individuals in the highest BPV tertile having the lowest eGFR and highest log ACR, cross-sectionally. However, the trajectories of eGFR and log ACR did not differ across BPV tertiles.
conclusionsCKD and markers of reduced kidney function occur more commonly in individuals with higher BPV; however, BPV does not influence trajectory of decline in kidney function over time in older adults who are in generally good health. CLINICAL TRIALS REGISTRATION: Trial Number NCT01038583 and ISRCTN83772183.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.