Evidence map›Paper›PMID 34519057›Full record

ArticleBritish journal of pharmacology2022

Evidence for tetrodotoxin-resistant spontaneous myogenic contractions of mouse isolated stomach that are dependent on acetylcholine.

Weigang Cai, Raj Makwana, Marilisa Straface, Armen Gharibans, Paul L R Andrews, Gareth J Sanger

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Weigang CaiBlizard Institute and the National Centre for Bowel Research, Barts The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID 0000-0001-9592-2160
Raj MakwanaBlizard Institute and the National Centre for Bowel Research, Barts The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID 0000-0003-2175-3530
Marilisa StrafaceBlizard Institute and the National Centre for Bowel Research, Barts The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Armen GharibansAuckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand.
Paul L R AndrewsDivision of Biomedical Sciences, St George's University of London, London, UK.ORCID 0000-0001-7099-6964
Gareth J SangerBlizard Institute and the National Centre for Bowel Research, Barts The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID 0000-0002-4231-1945
Queen Mary University of London · GBSt George's, University of London · GBUniversity of Auckland · NZ

Funding

Medical Research Council G0900805
6 · The paper itself

Abstract

background and purposeGastric pacemaker cells, interstitial cells of Cajal (ICC), are believed to initiate myogenic (non-neuronal) contractions. These become damaged in gastroparesis, associated with dysrhythmic electrical activity and nausea. We utilised mouse isolated stomach to model myogenic contractions and investigate their origin and actions of interstitial cells of Cajal modulators. EXPERIMENTAL APPROACH: Intraluminal pressure was recorded following distension with a physiological volume; tone, contraction amplitude and frequency were quantified. Compounds were bath applied. KEY

resultsThe stomach exhibited regular large amplitude contractions (median amplitude 9.0 [4.7-14.8] cmH CONCLUSIONS AND IMPLICATIONS: The distended mouse stomach exhibited myogenic contractions, resistant to blockade of neural activity by TTX. In the presence of TTX, these contractions were prevented or reduced by compounds blocking interstitial cells of Cajal activity or by atropine and enhanced by neostigmine (antagonised by atropine), suggesting involvement of non-neuronal ACh in their regulation.

Indexed as

AcetylcholineNeostigmineAnimalsAtropineElectric StimulationMiceMuscle ContractionStomachTetrodotoxinAcetylcholineAtropineNeostigmineTetrodotoxinAChANO1CaCCinterstitial cells of Cajalmyogenic contractionsnauseastomach

Identifiers

PMID34519057
PMCPMC9297954
OpenAlexW3199700588

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.