Evidence map›Paper›PMID 34519018›Full record

Trial reportCognitive, affective & behavioral neuroscience2022

Divergent effects of oxytocin on "mind-reading" in healthy males.

Ana Macchia, Paul Theo Zebhauser, Stephanie Salcedo, Bethany Burum, Edward Gold, Miguel Alonso-Alonso, Alvaro Pascual-Leone, Daniel Gilbert, Anna-Katharine Brem

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cognitive, affective & behavioral neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Oxytocin does not stand alone.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Article
  3. Oxytocin-a social peptide? Deconstructing the evidence.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Ana MacchiaMax Planck Institute of Psychiatry, Munich, Germany.ORCID 0000-0001-7002-0793
Paul Theo ZebhauserDepartment of Neurology, Klinikum Rechts der Isar der Technischen Universität München, Munich, Germany.
Stephanie SalcedoDepartment of Psychology, Harvard University, Cambridge, MA, USA.
Bethany BurumDepartment of Psychology, Harvard University, Cambridge, MA, USA.
Edward GoldBerenson-Allen Center for Noninvasive Brain Stimulation, Division of Interventional Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Miguel Alonso-AlonsoBerenson-Allen Center for Noninvasive Brain Stimulation, Division of Interventional Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Alvaro Pascual-LeoneGuttmann Brain Health Institute, Institut Guttmann, Universitat Autonoma Barcelona, Barcelona, Spain.
Daniel GilbertDepartment of Psychology, Harvard University, Cambridge, MA, USA.
Anna-Katharine BremMax Planck Institute of Psychiatry, Munich, Germany. katy.brem@gmail.com.
Harvard University · USBeth Israel Deaconess Medical Center · USTUM Klinikum · DEUniversität Ulm · DEUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The neuropeptide oxytocin (OT) has been associated with a broad range of human behaviors, particularly in the domain of social cognition, and is being discussed to play a role in a range of psychiatric disorders. Studies using the Reading The Mind In The Eyes Test (RMET) to investigate the role of OT in mental state recognition reported inconsistent outcomes. The present study applied a randomized, double-blind, cross-over design, and included measures of serum OT. Twenty healthy males received intranasal placebo or OT (24 IU) before performing the RMET. Frequentist and Bayesian analyses showed that contrary to previous studies (Domes et al., 2007; Radke & de Bruijn, 2015), individuals performed worse in the OT condition compared to the placebo condition (p = 0.023, Cohen's d = 0.55, 95% confidence interval [CI] [0.08, 1.02], BF

Indexed as

OxytocinAdministration, IntranasalBayes TheoremDouble-Blind MethodHumansMaleOxytocinOxytocinRMETSocial cognitionTheory of mind

Identifiers

PMID34519018
PMCPMC8791897
OpenAlexW3199333879

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.