Evidence map›Paper›PMID 34518958›Full record

ArticleArchives of sexual behavior2021

Genome-Wide Linkage and Association Study of Childhood Gender Nonconformity in Males.

Alan R Sanders, Gary W Beecham, Shengru Guo, Khytam Dawood, Gerulf Rieger, Ritesha S Krishnappa, Alana B Kolundzija, J Michael Bailey, Eden R Martin

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of sexual behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Alan R SandersDepartment of Psychiatry and Behavioral Sciences, NorthShore University HealthSystem Research Institute, 1001 University Place, Evanston, IL, 60201, USA. alan.sanders.md@gmail.com.ORCID 0000-0001-6629-4011
Gary W BeechamJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Shengru GuoJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Khytam DawoodDepartment of Psychology, Pennsylvania State University, University Park, PA, USA.
Gerulf RiegerDepartment of Psychology, University of Essex, Colchester, UK.
Ritesha S KrishnappaDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, Elmhurst, NY, USA.
Alana B KolundzijaCollective Impact, Washington, DC, USA.
J Michael BaileyDepartment of Psychology, Northwestern University, Evanston, IL, USA.
Eden R MartinJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
University of Miami · USCommunity Impact · USIcahn School of Medicine at Mount Sinai · USNorthShore University HealthSystem · USNorthwestern University · USPennsylvania State University · USUniversity of Essex · GB

Funding

Molecular Genetic Study of Sexual OrientationR01HD041563 · NICHD · NORTHSHORE UNIV HEALTHSYSTEM RES INST · PI SANDERS, ALAN R · 2003 to 2007
$3.7M
Meta-Analysis of Male Sexual OrientationR21HD080410 · NICHD · ENDEAVOR HEALTH CLINICAL OPERATIONS · PI MARTIN, EDEN R., SANDERS, ALAN R · 2016 to 2017
$439k
Eunice Kennedy Shriver National Institute of Child Health and Human Development R01HD041563Eunice Kennedy Shriver National Institute of Child Health and Human Development R21HD080410NICHD NIH HHS R01 HD041563NICHD NIH HHS R21 HD080410
6 · The paper itself

Abstract

Male sexual orientation is influenced by environmental and complex genetic factors. Childhood gender nonconformity (CGN) is one of the strongest correlates of homosexuality with substantial familiality. We studied brothers in families with two or more homosexual brothers (409 concordant sibling pairs in 384 families, as well as their heterosexual brothers), who self-recalled their CGN. To map loci for CGN, we conducted a genome-wide linkage scan (GWLS) using SNP genotypes. The strongest linkage peaks, each with significant or suggestive two-point LOD scores and multipoint LOD score support, were on chromosomes 5q31 (maximum two-point LOD = 4.45), 6q12 (maximum two-point LOD = 3.64), 7q33 (maximum two-point LOD = 3.09), and 8q24 (maximum two-point LOD = 3.67), with the latter not overlapping with previously reported strongest linkage region for male sexual orientation on pericentromeric chromosome 8. Family-based association analyses were used to identify associated variants in the linkage regions, with a cluster of SNPs (minimum association p = 1.3 × 10

Indexed as

Gender IdentityGenome-Wide Association StudyGenetic LinkageHeterosexualityHomosexuality, MaleHumansMaleSiblingsChildhood gender nonconformityComplex traitGenome-wide linkage scanGWASMale sexual orientation

Identifiers

PMID34518958
PMCPMC8604823
OpenAlexW3200706588

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.