ArticleNature materials2022
A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids.
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Article in Nature materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.
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118citing papers in PubMed
11.2field-weighted citation impact, top 1% of its field
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Who cites it
118 citing papers in PubMed, 181 citations in OpenAlex.
- A single-chain derivative of an integrin-activating antibody potentiates organoid growth in Matrigel and collagen hydrogels.Nature biotechnology · 2026Article
- A pancreatic cancer organoid-macrophage co-culture using starPEG-heparin hydrogel deciphers tumor-immune cell interactions.NPJ precision oncology · 2026Article
- Shape factor analysis as a quantitative framework for assessing spheroid and organoid morphology and invasiveness.APL bioengineering · 2026Article
- Review
- The role of gastric cancer patient-derived organoids in precision medicine: Clinicians' perspective.Stem cell reports · 2026Article
- A ternary association of KRas, EphA2, and integrins controls PDAC cell behavior.The Journal of biological chemistry · 2026Article
- Ovarian Extracellular Matrix Mechanics Regulate Oocyte-Follicle Interactions During Female Reproductive Aging.Aging cell · 2026Article
- Bioengineering advances in pancreatic cancer organoids for reproducible tumor microenvironment modeling.iScience · 2026Review
- Tumor organoid platform design for drug response modeling: culture architecture, microenvironmental complexity, and AI-assisted readouts.Archives of pharmacal research · 2026Review
- Development of a Synthetic Hydrogel to Foster Microvascularization of an Endometriosis Microphysiological System.Advanced healthcare materials · 2026Article
- Progress and challenges in the development of advanced pancreatic cancer organoids.Journal of experimental & clinical cancer research : CR · 2026Review
- Bottom-Up Programming of Cell States in Cancer Organoids with Defined Synthetic Adhesion Cues.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Dual targeting of PI3Kγ and STING overcomes regulatory B cell- and myeloid cell-driven immune suppression in pancreatic cancer.Nature cancer · 2026Article
- Mechanochemical regulation of organoid morphogenesis: Integrated signaling circuits in engineered microenvironments.Materials today. Bio · 2026Review
- Shape Factor Analysis as a Quantitative Framework for Assessing Spheroid and Organoid Morphology and Invasiveness.bioRxiv : the preprint server for biology · 2026Article
- GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Estrogen Production in Pancreatic Cancer Shapes a Tumor-Suppressive Stromal Microenvironment.Cancer research · 2026Article
- From organoid culture to manufacturing: technologies for reproducible and scalable organoid production.npj biomedical innovations · 2026Review
- Parabiosis, Assembloids, Organoids (PAO).Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Reconstructing the Islets: Advances in 3D Pancreatic Organoid Models for Functional β-Cell Replacement.International journal of molecular sciences · 2026Review
58 more citing papers are in PubMed but not listed here.
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Authors and funding
30 authors at 6 institutions in 2 countries.
Christopher R BelowCancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0003-1545-6281
Joanna KellyCancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.
Alexander BrownCentre for Gynepathology Research, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Jonathan D HumphriesWellcome Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0002-8953-7079
Colin HuttonCancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.
Jingshu XuCancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.
Brian Y LeeCancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.
Celia CintasCancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0001-8730-9171
Xiaohong ZhangCancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.
Victor Hernandez-GordilloCentre for Gynepathology Research, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Linda StockdaleCentre for Gynepathology Research, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Matthew A GoldsworthyManchester Royal Infirmary, Manchester, UK.
Joe GeraghtyManchester Royal Infirmary, Manchester, UK.
Lucy FosterManchester Royal Infirmary, Manchester, UK.
Derek A O'ReillyManchester Royal Infirmary, Manchester, UK.
Barbara ScheddingInstitute for Physiological Chemistry and Pathobiochemistry, University of Muenster, Muenster, Germany.
Janet AskariWellcome Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
Jessica BurnsWellcome Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
Nigel HodsonBioAFM Laboratory, Bioimaging Core Facility, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
Duncan L SmithCancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.
Catherine LallyCancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.
Garry AshtonCancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.
David KnightBiological Mass Spectrometry Core Facility, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
Aleksandr MironovElectron Microscopy Core Facility, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
Antonia BanyardCancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.
Johannes A EbleInstitute for Physiological Chemistry and Pathobiochemistry, University of Muenster, Muenster, Germany.
Jennifer P MortonCancer Research UK Beatson Institute, Glasgow, UK.
Martin J HumphriesWellcome Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0002-4331-6967
Linda G GriffithCentre for Gynepathology Research, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. griff@mit.edu.ORCID http://orcid.org/0000-0002-1801-5548
Claus JørgensenCancer Research UK Manchester Institute, The University of Manchester, Manchester, UK. Claus.jorgensen@manchester.ac.uk.ORCID http://orcid.org/0000-0002-7841-943X
University of Manchester · GBManchester Royal Infirmary · GBMassachusetts Institute of Technology · USWellcome Centre for Cell-Matrix Research · GBCancer Research UK Scotland Institute · GBManchester Metropolitan University · GB
Funding
Interdepartmental Biotechnology Training ProgramT32GM008334 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WITTRUP, KARL DANE · 1989 to 2018
$15.2MGuMI: New In Vitro Platforms to Parse the Human Gut Epithelial-Microbiome-Immune AxisR01EB021908 · NIBIB · NORTHEASTERN UNIVERSITY · PI CARRIER, REBECCA L, GRIFFITH, LINDA G · 2016 to 2020
$5.2MCancer Research UK 19258Cancer Research UK 21671Cancer Research UK 29996Cancer Research UK A19258Cancer Research UK A21671Cancer Research UK C13329/A21671NIBIB NIH HHS R01 EB021908NIGMS NIH HHS T32 GM008334
Abstract
Experimental in vitro models that capture pathophysiological characteristics of human tumours are essential for basic and translational cancer biology. Here, we describe a fully synthetic hydrogel extracellular matrix designed to elicit key phenotypic traits of the pancreatic environment in culture. To enable the growth of normal and cancerous pancreatic organoids from genetically engineered murine models and human patients, essential adhesive cues were empirically defined and replicated in the hydrogel scaffold, revealing a functional role of laminin-integrin α
Indexed as
AdenocarcinomaPancreatic NeoplasmsAnimalsExtracellular MatrixHumansHydrogelsMiceOrganoidsTumor MicroenvironmentHydrogels
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.